{"id":6639,"date":"2022-03-23T20:49:18","date_gmt":"2022-03-23T11:49:18","guid":{"rendered":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/?p=6639"},"modified":"2022-03-31T19:58:25","modified_gmt":"2022-03-31T10:58:25","slug":"virushostinteraction","status":"publish","type":"post","link":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/general\/virushostinteraction.html","title":{"rendered":"Virus-Host Interaction"},"content":{"rendered":"<h2>Ras-PI3K\u30b7\u30b0\u30ca\u30eb\u3092\u4ecb\u3057\u305f\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30a6\u30a4\u30eb\u30b9\u611f\u67d3<\/h2>\n<p>\u6e96\u5099\u4e2d<\/p>\n<p><strong>\u3010\u95a2\u9023\u696d\u7e3e\u3011<\/strong><\/p>\n<ul>\n<li>A peptide derived from phosphoinositide 3-kinase inhibits endocytosis and influenza virus infection. Fujioka Y, Satoh A, Horiuchi K, Fujioka M, Tsutsumi K, Sasaki J, Nepal P, Kashiwagi S, Paudel S, Nishide S, Nanbo A, Sasaki T, &amp; Ohba Y. <em><strong>Cell Struct Funct<\/strong><\/em>\u00a044: 61-74, 2019<\/li>\n<\/ul>\n<p style=\"padding-left: 30px;\"><a href=\"http:\/\/www.jscb.gr.jp\/action\/thesis_winners.html\">\u65e5\u672c\u7d30\u80de\u751f\u7269\u5b66\u4f1a\u8ad6\u6587\u8cde<\/a><\/p>\n<h2>Ca<sup>2+<\/sup>\u30b7\u30b0\u30ca\u30eb\u3092\u4ecb\u3057\u305f\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30a6\u30a4\u30eb\u30b9\u306e\u5bbf\u4e3b\u7d30\u80de\u4fb5\u5165\u6a5f\u69cb<\/h2>\n<p>\u591a\u304f\u306e\u30a6\u30a4\u30eb\u30b9\u306f\u7d30\u80de\u306b\u4fb5\u5165\u3059\u308b\u969b\u306b\u7d30\u80de\u304c\u6301\u3064\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u6a5f\u69cb\u3092\u5229\u7528\u3057\u307e\u3059\u3002\u4f8b\u3048\u3070\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u306f\u30af\u30e9\u30b9\u30ea\u30f3\u4f9d\u5b58\u6027\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u3067\u7d30\u80de\u306b\u4fb5\u5165\u3059\u308b\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u79c1\u305f\u3061\u306e\u7814\u7a76\u304b\u3089\u3001Ras-PI3K\u30b7\u30b0\u30ca\u30eb\u306e\u6d3b\u6027\u5316\u3092\u4ecb\u3057\u3066\u3001\u30af\u30e9\u30b9\u30ea\u30f3\u975e\u4f9d\u5b58\u6027\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u3067\u3082\u4fb5\u5165\u53ef\u80fd\u306a\u3053\u3068\u304c\u8a3c\u660e\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u305d\u306e\u969b\u306b\u7d30\u80de\u5185\u30ab\u30eb\u30b7\u30a6\u30e0\u6fc3\u5ea6\u306e\u4e0a\u6607\u3092\u5f15\u304d\u91d1\u306b\u3001Ras-PI3K\u30b7\u30b0\u30ca\u30eb\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\uff08\u56f3\uff12\uff09\u3002<\/p>\n<p><a href=\"..\/wp-content\/uploads\/2014\/03\/end01.jpg\"><img loading=\"lazy\" class=\"alignnone size-medium wp-image-342\" src=\"..\/wp-content\/uploads\/2014\/03\/end01.jpg\" alt=\"end01\" width=\"300\" height=\"65\" srcset=\"https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/wp-content\/uploads\/2014\/03\/end01.jpg 600w, https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/wp-content\/uploads\/2014\/03\/end01-300x66.jpg 300w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p><strong>\u56f32\u3000\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u306b\u3088\u308b\u7d30\u80de\u5185\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30aa\u30f3\u6fc3\u5ea6\u306e\u4e00\u904e\u6027\u4e0a\u6607<\/strong><br \/>\n\u57f9\u990a\u7d30\u80de\u306b\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30aa\u30f3\u6fc3\u5ea6\u3092\u30e2\u30cb\u30bf\u30fc\u3059\u308bFRET\u30bb\u30f3\u30b5\u30fc\u3092\u767a\u73fe\u3055\u305b\u3001\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u5f8c\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u52d5\u614b\u3092\u751f\u304d\u305f\u7d30\u80de\u3067\u89b3\u5bdf\u3057\u305f\u3002\u611f\u67d3\u76f4\u5f8c\u306b\u3001\u8907\u6570\u56de\u306e\u7d30\u80de\u5185\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30aa\u30f3\u6fc3\u5ea6\u306e\u4e00\u904e\u7684\u4e0a\u6607\u304c\u8d77\u3053\u3063\u305f\u3002<\/p>\n<p>\u3055\u3089\u306b\u89e3\u6790\u3092\u9032\u3081\u308b\u3068\u3001\u30a6\u30a4\u30eb\u30b9\u304c\u611f\u67d3\u3057\u305f\u6642\u306b\u751f\u3058\u308b\u30ab\u30eb\u30b7\u30a6\u30e0\u6fc3\u5ea6\u4e0a\u6607\u3092\u304d\u3063\u304b\u3051\u306b\u3001Ras-PI3K\u30b7\u30b0\u30ca\u30eb\u306e\u307f\u306a\u3089\u305a\u69d8\u3005\u306a\u30b7\u30b0\u30ca\u30eb\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u304c\u767a\u52d5\u3057\u3001\u7a2e\u3005\u306e\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u304c\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\uff08\u56f3\uff13\uff09\u3002<\/p>\n<p>\u3059\u306a\u308f\u3061\u3001\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30a6\u30a4\u30eb\u30b9\u306f\u5bbf\u4e3b\u7d30\u80de\u5185\u30ab\u30eb\u30b7\u30a6\u30e0\u6fc3\u5ea6\u306a\u3069\u3001\u7d30\u80de\u5185\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u6a5f\u69cb\u3092\u4e57\u3063\u53d6\u308b\u3053\u3068\u3067\u3001\u7d30\u80de\u5185\u306b\u4fb5\u5165\u3057\u3084\u3059\u3044\u74b0\u5883\u3092\u4f5c\u308a\u51fa\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u30e2\u30c7\u30eb\u304c\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u672c\u7814\u7a76\u306e\u3088\u3046\u306b\u3001\u30a6\u30a4\u30eb\u30b9\u3092\u7528\u3044\u3066\u7d30\u80de\u306e\u6a5f\u80fd\u3092\u63a2\u6c42\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u3053\u308c\u307e\u3067\u306f\u660e\u3089\u304b\u3067\u306f\u306a\u304b\u3063\u305f\u7d30\u80de\u306b\u6f5c\u3080\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u304c\u52a0\u901f\u3059\u308b\u3082\u306e\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<p><a href=\"..\/wp-content\/uploads\/2014\/03\/end02.jpg\"><img loading=\"lazy\" class=\"alignnone size-medium wp-image-343\" src=\"..\/wp-content\/uploads\/2014\/03\/end02.jpg\" alt=\"end02\" width=\"300\" height=\"160\" srcset=\"https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/wp-content\/uploads\/2014\/03\/end02.jpg 489w, https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/wp-content\/uploads\/2014\/03\/end02-300x160.jpg 300w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p><strong>\u56f33\u3000\u30ab\u30eb\u30b7\u30a6\u30e0\u30b7\u30b0\u30ca\u30eb\u3092\u4ecb\u3057\u305f\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30a6\u30a4\u30eb\u30b9\u306e\u4fb5\u5165\u6a5f\u69cb<\/strong><br \/>\n\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30a6\u30a4\u30eb\u30b9\u306f\u7d30\u80de\u306b\u5438\u7740\u3059\u308b\u3068\u3059\u3050\u3055\u307e\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u6fc3\u5ea6\u4e0a\u6607\u2192RhoA\u6d3b\u6027\u5316\u2192\u30ab\u30eb\u30b7\u30a6\u30e0\u6fc3\u5ea6\u4e0a\u6607\u3068\u3044\u3046\u30b7\u30b0\u30ca\u30eb\u3092\u767a\u52d5\u3055\u305b\u3001\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u3092\u4ea2\u9032\u3059\u308b\u3053\u3068\u3067\u52b9\u7387\u7684\u306b\u7d30\u80de\u306b\u4fb5\u5165\u3059\u308b\u3002<\/p>\n<h2>\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30a6\u30a4\u30eb\u30b9\u306e\u5bbf\u4e3b\u53d7\u5bb9\u4f53\u306e\u540c\u5b9a<\/h2>\n<p>\u3055\u3089\u306b\u3001\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30a6\u30a4\u30eb\u30b9\u304c\u7d30\u80de\u5185\u30ab\u30eb\u30b7\u30a6\u30e0\u6fc3\u5ea6\u3092\u4e0a\u6607\u3055\u305b\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u8abf\u3079\u305f\u3068\u3053\u308d\u3001\u96fb\u4f4d\u4f9d\u5b58\u6027\u30ab\u30eb\u30b7\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb\u304c\u9375\u3067\u3042\u308b\u3053\u3068\u304c\u89e3\u308a\u307e\u3057\u305f\u3002\u96fb\u4f4d\u4f9d\u5b58\u6027\u30ab\u30eb\u30b7\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb\u306e\u963b\u5bb3\u85ac\u3067\u3042\u308b\u30ab\u30eb\u30b7\u30a6\u30e0\u30d6\u30ed\u30c3\u30ab\u30fc\u306fin vitro\u3060\u3051\u3067\u306a\u304f\u30de\u30a6\u30b9\u3092\u7528\u3044\u305fin vivo\u3067\u306e\u7cfb\u3084\u30d2\u30c8\u7d30\u80de\u3092\u7528\u3044\u305fex vivo\u306e\u5b9f\u9a13\u7cfb\u3067\u3082\u611f\u67d3\u6291\u5236\u52b9\u679c\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u4eca\u5f8c\u306e\u6297\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u85ac\u958b\u767a\u3078\u306e\u5c55\u958b\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002&lt;\/p<\/p>\n<p><strong>\u3010\u95a2\u9023\u696d\u7e3e\u3011<\/strong><\/p>\n<ul>\n<li>A Ca<sup>2+<\/sup>-dependent signalling circuit regulates influenza A virus internalisation and infection. Fujioka Y, Tsuda M, Nanbo A, Hattori T, Sasaki J, Sasaki T, Miyazaki T &amp; Ohba Y.<em><strong> Nat. Commun.<\/strong><\/em> 4: 2763, 2013\n<ul>\n<li><a href=\"http:\/\/www.hokudai.ac.jp\/news\/131114_pr_med.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">\u5317\u5927\u306b\u3088\u308b\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u8a18\u4e8b<\/a><\/li>\n<li>Yahoo\u30cb\u30e5\u30fc\u30b9<\/li>\n<li>\u5317\u6d77\u9053\u306e\u30cb\u30e5\u30fc\u30b9\u30fb\u6c17\u8c61\u60c5\u5831\u3001\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u30cb\u30e5\u30fc\u30b9\u5317\u6d77\u9053\uff08\u3068\u3082\u306bNHK\u300111\/14\uff09<\/li>\n<\/ul>\n<\/li>\n<li>A Voltage-Dependent Ca<sup>2+<\/sup> Channel Participates in Influenza A Virus Entry into Mammalian Cells. Fujioka Y, Nishide S, Ose T, Suzuki T, Kato I, Fukuhara H, Fujioka M, Horiuchi K, Satoh A, Nepal P, Kashiwagi S, Wang J, Horiguchi M, Sato Y, Paudel S, Nanbo A, Miyazaki T, Hasegawa H, Maenaka K, Ohba Y. <em><strong>Cell Host Microbe<\/strong><\/em> 23: 809-818, 2018<\/li>\n<\/ul>\n<p style=\"padding-left: 30px;\"><a href=\"https:\/\/www.cell.com\/cell-host-microbe\/fulltext\/S1931-3128(18)30273-7\" target=\"_blank\" rel=\"noopener noreferrer\">Previews<\/a><a href=\"https:\/\/www.hokudai.ac.jp\/news\/180523_pr.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><br \/>\n\u5317\u5927\u306b\u3088\u308b\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u8a18\u4e8b<\/a><a href=\"https:\/\/newswitch.jp\/p\/13115\"><br \/>\n<\/a><a href=\"http:\/\/first.lifesciencedb.jp\/archives\/18288\" target=\"_blank\" rel=\"noopener noreferrer\">\u30e9\u30a4\u30d5\u30b5\u30a4\u30a8\u30f3\u30b9\u65b0\u7740\u8ad6\u6587\u30ec\u30d3\u30e5\u30fc<br \/>\n<\/a><a href=\"https:\/\/news.mynavi.jp\/article\/20180529-637561\/\" target=\"_blank\" rel=\"noopener noreferrer\">\u30de\u30a4\u30ca\u30d3\u30cb\u30e5\u30fc\u30b9<\/a><a href=\"https:\/\/newswitch.jp\/p\/13115\"><br \/>\n<\/a><a href=\"https:\/\/yomidr.yomiuri.co.jp\/article\/20180607-OYTET50009\/\" target=\"_blank\" rel=\"noopener noreferrer\">\u8aad\u58f2\u65b0\u805e<\/a><a href=\"https:\/\/newswitch.jp\/p\/13115\"><br \/>\n<\/a><a href=\"https:\/\/www.nikkan.co.jp\/articles\/view\/00475170\" target=\"_blank\" rel=\"noopener noreferrer\">\u65e5\u520a\u5de5\u696d\u65b0\u805e<\/a><a href=\"https:\/\/newswitch.jp\/p\/13115\"><br \/>\n<\/a><a href=\"http:\/\/www.microbe.tv\/twiv\/twiv-495\/\" target=\"_blank\" rel=\"noopener noreferrer\">This week in Virology<\/a><a href=\"https:\/\/newswitch.jp\/p\/13115\"><br \/>\n<\/a><a href=\"https:\/\/issuu.com\/asiaresearchnews\/docs\/arn-2019_online_magazine?e=1764199\/67236192\" target=\"_blank\" rel=\"noopener noreferrer\">Asia Research News<\/a><a href=\"https:\/\/newswitch.jp\/p\/13115\"><br \/>\n<\/a>\u4ed6<\/p>\n<p>\u7d30\u80de\u751f\u7406\u306e\u4ed6\u306e\u7814\u7a76\u306b\u3064\u3044\u3066\u306f<a href=\"https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/research.html\">\u3053\u3061\u3089<\/a>\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ras-PI3K\u30b7\u30b0\u30ca\u30eb\u3092\u4ecb\u3057\u305f\u30a4\u30f3\u30d5\u30eb &hellip; <\/p>\n","protected":false},"author":2,"featured_media":6525,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[8],"tags":[],"_links":{"self":[{"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/wp-json\/wp\/v2\/posts\/6639"}],"collection":[{"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/wp-json\/wp\/v2\/comments?post=6639"}],"version-history":[{"count":7,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/wp-json\/wp\/v2\/posts\/6639\/revisions"}],"predecessor-version":[{"id":6962,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/wp-json\/wp\/v2\/posts\/6639\/revisions\/6962"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/wp-json\/wp\/v2\/media\/6525"}],"wp:attachment":[{"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/wp-json\/wp\/v2\/media?parent=6639"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/wp-json\/wp\/v2\/categories?post=6639"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/wp-json\/wp\/v2\/tags?post=6639"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}