{"id":6628,"date":"2022-03-23T20:15:03","date_gmt":"2022-03-23T11:15:03","guid":{"rendered":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/?p=6628"},"modified":"2022-03-31T19:56:59","modified_gmt":"2022-03-31T10:56:59","slug":"signal-transduction","status":"publish","type":"post","link":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/uncategorized\/signal-transduction.html","title":{"rendered":"Cell Signaling"},"content":{"rendered":"<h2>\u7d30\u80de\u5185\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3068\u306f<\/h2>\n<p>\u7d30\u80de\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306f\u4e00\u822c\u306b\u3001\u7d30\u80de\u8868\u9762\u306e\u53d7\u5bb9\u4f53\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u30ea\u30ac\u30f3\u30c9\u7269\u8cea\u304c\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u3092\u5f15\u304d\u91d1\u306b\u3001\u7d30\u80de\u5185\u3067\u9023\u7d9a\u7684\u306b\u5206\u5b50\u9593\u76f8\u4e92\u4f5c\u7528\u304c\u8d77\u3053\u308a\u3001\u30b7\u30b0\u30ca\u30eb\u304c\u79e9\u5e8f\u6b63\u3057\u304f\u5897\u5e45\u30fb\u4f1d\u9054\u3055\u308c\u3066\u3044\u304d\u307e\u3059\u3002\u305d\u306e\u7d50\u679c\u3001\u7d30\u80de\u5185\u5916\u306b\u5b58\u5728\u3059\u308b\u7279\u7570\u7684\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7ffb\u8a33\u5f8c\u4fee\u98fe\u3084\u69cb\u9020\u5909\u5316\u306a\u3069\u304c\u751f\u3058\u3001\u305d\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6d3b\u6027\u3084\u6a5f\u80fd\u304c\u5909\u5316\u3057\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u7d30\u80de\u5185\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u304c\u79e9\u5e8f\u6b63\u3057\u304f\u6642\u9593\u7684\u30fb\u7a7a\u9593\u7684\u306b\u53b3\u5bc6\u306b\u5236\u5fa1\u3055\u308c\u308b\u3053\u3068\u3067\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u5236\u5fa1\u3084\u7d30\u80de\u5f62\u614b\u306e\u5909\u5316\u306a\u3069\u306e\u8868\u73fe\u5f62\u304c\u898f\u5b9a\u3055\u308c\u3001\u6700\u7d42\u7684\u306b\u306f\u751f\u4f53\u53cd\u5fdc\u304c\u5236\u5fa1\u3055\u308c\u3066\u3044\u308b\u306e\u3067\u3059\u3002<\/p>\n<p>\u7d30\u80de\u5185\u306e\u300c\u3044\u3064\u3001\u3069\u3053\u3067\u3001\u3069\u306e\u7a0b\u5ea6\u3001\u3069\u306e\u300d\u30b7\u30b0\u30ca\u30eb\u5206\u5b50\u304c\u6d3b\u6027\u5316\u3057\u3066\u3044\u308b\u304b\u3092\u89e3\u6790\u3059\u308b\u306e\u306b\u529b\u3092\u767a\u63ee\u3059\u308b\u306e\u304c\u300c\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u300d\u3001\u3068\u308a\u308f\u3051\u5b9a\u91cf\u7684\u306a\u300c\u86cd\u5149\u30d0\u30a4\u30aa\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u300d\u3067\u3059\u3002<\/p>\n<h2>Ras-PI3K\u30b7\u30b0\u30ca\u30eb\u306b\u3088\u308b\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u5236\u5fa1\u6a5f\u69cb<\/h2>\n<p> \u4f4e\u5206\u5b50\u91cfG\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308bRas\u306f\u3001\u4e0b\u6d41\u3067\u50cd\u304f\u8907\u6570\u306e\u6a19\u7684\u56e0\u5b50\u3092\u300c\u3044\u3064\u3001\u3069\u3053\u3067\u300d\u6d3b\u6027\u5316\u3055\u305b\u308b\u304b\u5de7\u5999\u306b\u5236\u5fa1\u3059\u308b\u3053\u3068\u3067\u3001\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306b\u304a\u3044\u3066\u591a\u5f69\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002\u751f\u304d\u305f\u7d30\u80de\u306b\u304a\u3051\u308bRas\u3068\u305d\u306e\u6a19\u7684\u56e0\u5b50\u304c\u5f62\u6210\u3059\u308b\u8907\u5408\u4f53\u306e\u6319\u52d5\u3092BiFC\u6cd5\u3067\u53ef\u8996\u5316\u3057\u305f\u3068\u3053\u308d\u3001Ras\u3068phosphoinositide 3-kinase\uff08PI3K\uff09\u306e\u8907\u5408\u4f53\u306f\u3001\u4ed6\u306e\u6a19\u7684\u56e0\u5b50\u3068\u306f\u7570\u306a\u308a\u7d30\u80de\u819c\u3060\u3051\u3067\u306a\u304f\u30a8\u30f3\u30c9\u30be\u30fc\u30e0\u306b\u3082\u5c40\u5728\u3057\u3066\u3044\u307e\u3057\u305f\uff08\u56f31\uff09\u3002\u307e\u305f\u3001Ras-PI3K\u8907\u5408\u4f53\u304c\u7d30\u80de\u819c\u304b\u3089\u30a8\u30f3\u30c9\u30be\u30fc\u30e0\u306b\u79fb\u884c\u3057\u3001\u30a8\u30f3\u30c9\u30be\u30fc\u30e0\u304b\u3089\u767a\u4fe1\u3059\u308b\u30b7\u30b0\u30ca\u30eb\u304c\u3001\u30af\u30e9\u30b9\u30ea\u30f3\u975e\u4f9d\u5b58\u6027\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u306e\u5236\u5fa1\u306b\u91cd\u8981\u306a\u3053\u3068\u3082\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002 <\/p>\n<p> \u672c\u7814\u7a76\u306b\u3088\u308a\u3001\u3053\u308c\u307e\u3067\u7d30\u80de\u819c\u304c\u4e3b\u6226\u5834\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u304d\u305fRas-PI3K\u30b7\u30b0\u30ca\u30eb\u306b\u30a8\u30f3\u30c9\u30be\u30fc\u30e0\u3068\u3044\u3046\u65b0\u305f\u306a\u6d3b\u8e8d\u306e\u5834\u3092\u898b\u51fa\u3059\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002\u3053\u306e\u767a\u898b\u306f\u3001\u30c0\u30a4\u30ca\u30df\u30c3\u30af\u306b\u5909\u5316\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u76f8\u4e92\u4f5c\u7528\u3092\u5b9f\u969b\u306b\u898b\u308b\u3053\u3068\u304b\u3089\u30b9\u30bf\u30fc\u30c8\u3057\u305f\u6210\u679c\u3067\u3042\u308a\u3001 \u201cseeing is believing\u201d\u3092\u307e\u3055\u306b\u4f53\u73fe\u3057\u305f\u597d\u4f8b\u3067\u3059\u3002\u73fe\u5728\u306f\u3001Ras-PI3K\u304c\u30a8\u30f3\u30c9\u30be\u30fc\u30e0\u306b\u79fb\u884c\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u63a2\u7d22\u3057\u3066\u3044\u307e\u3059\u3002 <\/p>\n<p><a href=\"..\/wp-content\/uploads\/2014\/03\/ras_pi3k.jpg\"><img loading=\"lazy\" class=\"alignnone size-medium wp-image-346\" src=\"..\/wp-content\/uploads\/2014\/03\/ras_pi3k.jpg\" alt=\"ras_pi3k\" width=\"360\" height=\"120\" srcset=\"https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/wp-content\/uploads\/2014\/03\/ras_pi3k.jpg 642w, https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/wp-content\/uploads\/2014\/03\/ras_pi3k-300x101.jpg 300w\" sizes=\"(max-width: 360px) 100vw, 360px\" \/><\/a><\/p>\n<p><strong>\u56f31\u3000Ras-PI3K\u8907\u5408\u4f53\u306f\u30a8\u30f3\u30c9\u30be\u30fc\u30e0\u306b\u5c40\u5728\u3059\u308b<\/strong><br \/>\nBiFC\u6cd5\u3092\u7528\u3044\u3066Ras\u3068\u6a19\u7684\u56e0\u5b50\u304c\u5f62\u6210\u3059\u308b\u8907\u5408\u4f53\u3092\u53ef\u8996\u5316\u3057\u305f\u3002Ras-PI3K\u8907\u5408\u4f53\u306f\u7d30\u80de\u819c\u3060\u3051\u3067\u306a\u304f\u3001\u30a8\u30f3\u30c9\u30be\u30fc\u30e0\u306b\u3082\u5c40\u5728\u3057\u305f\u3002<\/p>\n<p><strong>\u3010\u95a2\u9023\u696d\u7e3e\u3011<\/strong><\/p>\n<ul>\n<li>\n<p>Visualization of Ras-PI3K interaction in the endosome using BiFC. Tsutsumi K, Fujioka Y, Tsuda M, Kawaguchi H,  &amp;  Ohba Y. <em><strong>Cell Signal.<\/strong><\/em> 21: 1672-1679, 2009<\/p>\n<\/li>\n<\/ul>\n<p>\u7d30\u80de\u751f\u7406\u306e\u4ed6\u306e\u7814\u7a76\u306b\u3064\u3044\u3066\u306f<a href=\"https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/research.html\">\u3053\u3061\u3089<\/a>\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7d30\u80de\u5185\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3068\u306f \u7d30\u80de\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054 &hellip; <\/p>\n","protected":false},"author":2,"featured_media":64,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/wp-json\/wp\/v2\/posts\/6628"}],"collection":[{"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/wp-json\/wp\/v2\/comments?post=6628"}],"version-history":[{"count":7,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/wp-json\/wp\/v2\/posts\/6628\/revisions"}],"predecessor-version":[{"id":6961,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/wp-json\/wp\/v2\/posts\/6628\/revisions\/6961"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/wp-json\/wp\/v2\/media\/64"}],"wp:attachment":[{"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/wp-json\/wp\/v2\/media?parent=6628"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/wp-json\/wp\/v2\/categories?post=6628"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/wp-json\/wp\/v2\/tags?post=6628"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}