{"id":212,"date":"2014-03-22T19:04:06","date_gmt":"2014-03-22T10:04:06","guid":{"rendered":"http:\/\/cp.med.hokudai.ac.jp\/wp\/?page_id=212"},"modified":"2023-11-20T10:00:08","modified_gmt":"2023-11-20T01:00:08","slug":"publication","status":"publish","type":"page","link":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cp.med\/Root\/publication.html","title":{"rendered":"\u7814\u7a76\u696d\u7e3e"},"content":{"rendered":"

(2023.11.20\u66f4\u65b0\uff09<\/p>\r\n\r\n

\u82f1\u6587\u539f\u8457\u8ad6\u6587<\/h2>\r\n

2023\u5e74<\/h3>\r\n

Safe and efficient oral allergy immunotherapy using one-pot-prepared mannan-coated allergen nanoparticles.\u3000Li S, Toriumi H, Takahashi D, Kamasaki T, Fujioka Y, Nagatoishi S, Li J, Liu Y, Hosokawa T, Tsumoto K, Ohba Y<\/u>, Katayama Y, Murakami D, Hase K, Mori K. Biomaterials<\/em><\/strong> 303: 122381 (2023) \r\nhttps:\/\/doi.org\/10.1016\/j.biomaterials.2023.122381<\/a>\r\n\r\n

Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5. Tamura T, Yamasoba D, Oda Y, Ito J, Kamasaki T, Nao N, Hashimoto R, Fujioka Y, Suzuki R, Wang L, Ito H, Kashima Y, Kimura I, Kishimoto M, Tsuda M, Sawa H, Yoshimatsu K, Yamamoto Y, Nagamoto T, Kanamune J, Suzuki Y, Ohba Y<\/u>, et al., Commun Biol<\/strong><\/em> 6 (2023) \r\nhttps:\/\/www.nature.com\/articles\/s42003-023-05081-w<\/a>\r\n\r\n

Interaction between PI3K and the VDAC2 channel tethers Ras-PI3K-positive endosomes to mitochondria and promotes endosome maturation.\u3000Satoh AO, Fujioka Y, Kashiwagi S, Yoshida A, Fujioka M, Sasajima H, Nanbo A, Amano M, Ohba Y<\/u>. Cell Reports<\/strong><\/em> 42: 112229 (2023) https:\/\/doi.org\/10.1016\/j.celrep.2023.112229<\/a><\/p>\r\n\r\n

2022\u5e74<\/h3>\r\n

Schlafen family member 11 indicates favorable prognosis of patients with head and neck cancer following platinum-based chemoradiotherapy. Hamada S, Kano S*, Murai J, Suzuki T, Tsushima N, Mizumachi T, Suzuki M, Takashima T, Taniyama D, Sakamoto N, Fujioka Y, Ohba Y<\/u>, Homma A. Front. Oncol.<\/em><\/strong> Sec. Head and Neck Cancer doi: 10.3389\/fonc.2022.978875<\/p>\r\n\r\n\r\n

Stimulation of the mitochondrial calcium uniporter mitigates chronic heart failure-associated ventricular arrhythmia in mice. Hagiwara H, Watanabe M, Fujioka Y, Kadosaka T, Koizumi T, Koya T, Nakao M, Kamada R, Temma T, Okada K, Moreno JA, Kwon O, Sabe H, Ohba Y<\/u>, Anzai T. Heart Rhythm.<\/em><\/strong>19:1725-1735, 2022<\/p>\r\n

Secretory glycoprotein NS1 plays a crucial role in the particle formation of flaviviruses. Tamura T, Torii S, Kajiwara K, Anzai I, Fujioka Y, Noda K, Taguwa S, Morioka Y, Suzuki R, Fauzyah Y, Ono C, Ohba Y<\/u>, Okada M, Fukuhara T, Matsuura Y.PLoS Pathog.<\/em><\/strong> 18:e1010593, 2022<\/p> \r\n

A method for the generation of pseudovirus particles bearing SARS coronavirus spike protein in high yields. Fujioka Y, Kashiwagi S, Yoshida A, Satoh AO , Fujioka M, Amano M, Yamauchi Y, Ohba Y<\/u>. Cell Struct Funct.<\/em><\/strong> 47:43-53, 2022<\/p>\r\n

Direct visualization of glucagon-like peptide-1 secretion by fluorescent fusion proteins. Tsuzuki A, Fujioka Y, Yoshida A, Kashiwagi S, Amano M, Hira T, Nakamura A, Miyoshi H, Atsumi T, Ohba Y<\/u>. J Diabetes Investig.<\/em><\/strong> 13:1134-1139,2022<\/p> \r\n

2020\u5e74<\/h3>\r\n

An Antiviral Drug Screening Platform with a FRET Biosensor for Measurement of Arenavirus Z Assembly. Mizutani T, Ohba Y<\/u>, Mizuta S, Yasuda J, Urata S. Cell Struct Funct.<\/em><\/strong> 45:155-163, 2020<\/p>\r\n

A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis. Tsukiyama T, Zou J, Kim J, Ogamino S, Shino Y, Masuda T, Merenda A, Matsumoto M, Fujioka Y, Hirose T, Terai S, Takahashi H, Ishitani T, Nakayama KI, Ohba Y<\/u>, Koo BK, Hatakeyama S. Nat Commun.<\/strong><\/em> 11:4586, 2020\r\n

Calcium Wave Promotes Cell Extrusion. Takeuchi Y, Narumi R, Akiyama R, Vitiello E, Shirai T, Tanimura N, Kuromiya K, Ishikawa S, Kajita M, Tada M, Harada Y, Akieda Y, Ishitani T, Fujioka Y, Ohba Y<\/u>, Yamada S, Hosokawa Y, Toyama Y, Matsui T, Fujita Y.\u00a0Curr Biol.<\/em><\/strong>30:670-681, e6, 2020<\/p>\r\n

2019\u5e74<\/h3>\r\n

Localization of BCR-ABL to stress granules contributes to its oncogenic function. Kashiwagi S, Fujioka Y, Kondo T, Satoh AO, Yoshida A, Fujioka M, Sasajima H, Amano M, Teshima T and Ohba Y<\/u>.\u00a0Cell Struct. Funct<\/em><\/strong>. 44: 195-204, 2019<\/p>\r\n

Folding latency of fluorescent proteins affects the mitochondrial localization of fusion proteins. Kashiwagi S, Fujioka Y, Satoh AO, Yoshida A, Fujioka M, Nepal P, Tsuzuki A, Aoki O, Paudel S, Sasajima H and Ohba Y<\/u>. Cell Struct. Funct.\u00a0<\/em><\/strong>44: 183-194, 2019<\/p>\r\n

Antibody-free digital influenza virus counting based on neuraminidase activity. Tabata VT, Minagawa Y, Kawaguchi Y, Ono M, Moriizumi Y, Yamayoshi S, Fujioka Y, Ohba Y, Kawaoka Y & Noji H.\u00a0Sci. Rep.<\/strong><\/em>\u00a09:\u00a01067,\u00a02019\u00a0\u00a0<\/p>\r\n

Development of immortalized human tumor endothelial cells from renal cancer. Maishi N, Kikuchi H, Sato M, Nagao-Kitamoto H, Annan DA, Baba S, Hojo T, Yanagiya M, Ohba Y<\/u>, Ishii G, Masutomi K, Shinohara N, Hida Y and Hida K.\u00a0Int. J. Mol. Sci.<\/em><\/strong> 20: pii: E4595, 2019<\/p>\r\n

Clinical efficacy and safety of first-line nilotinib therapy and evaluation of the clinical utility of the FRET-based drug sensitivity test. Kondo T, Fujioka M, Fujisawa S, Sato K, Tsuda M, Miyagishima T, Mori A, Iwasaki H, Kakinoki Y, Yamamoto S, Haseyama Y, Ando S, Shindo M, Ota S, Kurosawa M, Ohba Y<\/u>, Teshima T; North Japan Hematology Study Group (NJHSG). Int. J. Hematol.\u00a0<\/em><\/strong>110: 482-489, 2019<\/p>\r\n

A peptide derived from phosphoinositide 3-kinase inhibits endocytosis and influenza virus infection. Fujioka Y, Satoh AO, Horiuchi K, Fujioka M, Tsutsumi M, Sasaki J, Nepal P, Kashiwagi S, Paudel S, Nishide S, Nanbo A, Sasaki T and Ohba Y<\/u>.Cell Struct. Funct.\u00a0<\/em><\/strong>44: 61-74, 2019<\/p>\r\n

2018\u5e74<\/h3>\r\n

Budding of Ebola Virus Particles Requires the Rab11-Dependent Endocytic Recycling Pathway. A. Nanbo and Y. Ohba<\/u>. J. Infect. Dis.<\/strong><\/em>218(suppl_5): S388\u2013S396, 2018<\/p>\r\n

Infection of Epstein-Barr virus in type III latency modulates biogenesis of exosomes and the expression profile of exosomal miRNAs in the Burkitt lymphoma Mutu cell lines. A. Nanbo, H. Katano, M. Kataoka, S. Hoshina, T. Sekizuka, M. Kuroda and Y. Ohba<\/u>. Cancer<\/em><\/strong> 10(7): 237, 2018<\/p>\r\n

A Sialylated Voltage-Dependent Ca2+<\/sup>Channel Binds Hemagglutinin and Mediates Influenza A Virus Entry into Mammalian Cells.\u00a0Y. Fujioka,\u00a0S. Nishide, T. Ose,\u00a0T. Suzuki, I. Kato, H. Fukuhara,\u00a0M. Fujioka,\u00a0K. Horiuchi,\u00a0A. O. Satoh,\u00a0P. Nepal,\u00a0S. Kashiwagi,\u00a0J. Wang,\u00a0M. Horiguchi,\u00a0Y. Sato,\u00a0S. Paudel,\u00a0A. Nanbo,\u00a0T. Miyazaki,\u00a0H. Hasegawa,\u00a0K. Maenaka and Y. Ohba<\/span>.\u00a0Cell Host Microbe<\/em><\/strong>\u00a023(6): 809-818 (2018)<\/a><\/p>\r\n

Previews<\/a>
\u5317\u5927\u306b\u3088\u308b\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u8a18\u4e8b<\/a>
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\u65e5\u520a\u5de5\u696d\u65b0\u805e<\/a>
<\/a>This week in Virology<\/a>
Asia Research News<\/a>\u3000\u4ed6<\/p>\r\n

The role of transforming growth factor \u03b2 in cell-to-cell contact-mediated Epstein-Barr virus transmission. A. Nanbo, M. Ohashi, H. Yoshiyama and Y. Ohba<\/u>.\u00a0Front. Microbiol.<\/em><\/strong> 9: 984 (2018)<\/p>\r\n

Pretreatment evaluation of fluorescence resonance energy transfer\u2010based drug sensitivity test for patients with chronic myelogenous leukemia treated with dasatinib.T. Kondo, M. Fujioka, M. Tsuda, K. Murai, K. Yamaguchi, T. Miyagishima, M. Shindo, T. Nagashima, K. Wakasa, N. Fujimoto, S. Yamamoto, M. Yonezumi, S. Saito, S. Sato, K. Ogawa, T. Chou, R. Watanabe, Y. Kato, S. Takahashi, Y. Okano, J. Yamamoto, M. Ohta, H. Iijima, K. Oba, S. Kishino, J. Sakamoto, Y. Ishida, Y. Ohba<\/u> and T. Teshima. Cancer Sci.<\/em><\/strong> 109: 2256-2265 (2018)<\/p>\r\n

Epstein-Barr Virus Acquires Its Final Envelope on Intracellular Compartments With Golgi Markers. A. Nanbo, T. Noda and Y. Ohba<\/u>. Front. Microbiol.<\/em><\/strong>\u00a09: 454 (2018)<\/p>\r\n

Dermoscopic evaluation for skin grafts after surgery; neo-vascularization correlates with survival of skin grafts: a prospective study. S. Kitamura, T. Yanagi, Y. Inamura-Takashima, K. Imafuku, H. Hata, Y. Fujioka, Y. Ohba<\/u> and H. Shimizu. J. Dermatol. Sci.\u00a0<\/em><\/strong>90: 213-216 (2018)<\/p>\r\n

Ebola virus requires a host scramblase for externalization of phosphatidylserine on the surface of viral particles. A. Nanbo, J. Maruyama, M. Imai, M. Ujie, Y. Fujioka, S. Nishide, A. Takada, Y. Ohba<\/u> and Y. Kawaoka. PLoS Pathog.<\/em><\/strong> 14(1): e1006848 (2018)<\/p>\r\n

2017\u5e74<\/h3>\r\n

Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes. S. Kon, K. Ishibashi, H. Katoh, S. Kitamoto, T. Shirai, S. Tanaka, M. Kajita, S. Ishikawa, H. Yamauchi, Y. Yako, T. Kamasaki, T. Matsumoto, H. Watanabe, R. Egami, A. Sasaki, A. Nishikawa, I. Kameda, T. Maruyama, R. Narumi, T. Morita, Y. Sasaki, R. Enoki, S. Honma, H. Imamura, M. Oshima, T. Soga, J.I. Miyazaki, M.R. Duchen, J.M. Nam, Y. Onodera, S. Yoshioka, J. Kikuta, M. Ishii, M. Imajo, E. Nishida, Y. Fujioka, Y. Ohba<\/u>, T. Sato and Y. Fujita. Nat. Cell Biol.<\/em><\/strong> 9(5): 530-541 (2017)<\/p>\r\n

Improved FRET biosensor for the measurement of BCR-ABL activity in chronic myeloid leukemia cells. M. Horiguchi, M. Fujioka, T. Kondo, Y. Fujioka, X. Li, K. Horiuchi, A.O. Satoh, P. Nepal, S. Nishide, A. Nanbo, T. Teshima and Y. Ohba<\/u>. Cell. Struct. Funct.<\/em><\/strong> 42(1): 15-26\u00a0(2017)<\/a><\/p>\r\n

Rab5-regulated endocytosis plays a crucial role in apical extrusion of transformed cells. S. Saitoh, T. Maruyama, Y. Yako, M. Kajita, Y. Fujioka, Y. Ohba<\/u>, N. Kasai, N. Sugama, S. Kon, S. Ishikawa, T. Hayashi, T. Yamazaki, M. Tada and Y. Fujita. Proc. Natl. Acad. Sci. U.S.A.<\/em><\/strong> 114(12): E2327-E2336 (2017)<\/p>\r\n

A leukemogenic kinase, FIP1L1-PDGFRA, and a SUMO E3 ligase, PIAS1, form a positive crosstalk via their enzymatic activities. M. Ibata, J. Iwasaki, Y. Fujioka, K. Nakagawa, S. Darmanin, M. Onozawa, D. Hashimoto, Y. Ohba<\/u>, S. Hatakeyama, T. Teshima and T. Kondo. Cancer Sci.<\/em><\/strong> 108(2): 200-207, (2017)<\/p>\r\n

2016\u5e74<\/h3>\r\n

Epstein-Barr virus exploits host endocytic machinery for cell-to-cell viral transmission rather than a virological synapse. A. Nanbo, K. Kachi, H. Yoshiyama and Y. Ohba<\/span>. J. Gen. Virol<\/b>.<\/em> 97(11): 2989-3006\u00a0(2016)<\/p>\r\n

Tumour endothelial cells in high metastatic tumours promote metastasis via epigenetic dysregulation of biglycan. N. Maishi, Y. Ohba<\/span>, K. Akiyama, N. Ohga, J.I. Hamada, H. Nagao-Kitamoto, M. Alam, K. Yamamoto, T. Kawamoto, N. Inoue, A. Taketomi, M. Shindoh, Y. Hida and K. Hida. Sci. Rep<\/em>.<\/b> 6: 28039\u00a0(2016)<\/p>\r\n

Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia. R. Okumura, T. Kurakawa, T. Nakano, H. Kayama, M. Kinoshita, D. Motooka, K. Gotoh, T. Kimura, N. Kamiyama, T. Kusu, Y. Ueda, H. Wu, H. Iijima, S. Barman, H. Osawa, H. Matsuno, J. Nishimura, Y. Ohba<\/u>, S. Nakamura, T. Iida, M. Yamamoto, E. Umemoto, K. Sano and K. Takeda. Nature<\/em><\/strong> 532(7597): 117-121 (2016)<\/p>\r\n

Receptor activator of NF-\u03baB ligand induces cell adhesion and integrin \u03b12 expression via NF-\u03baB in head and neck cancers. T. Yamada, M. Tsuda, T. Wagatsuma, Y. Fujioka, M. Fujioka, A.O. Satoh, K. Horiuchi, S. Nishide, A. Nanbo, Y. Totsuka, H. Haga, S. Tanaka, M. Shindoh, and Y. Ohba<\/span>. Sci. Rep.<\/em><\/strong>\u00a06: 23545 (2016)<\/a><\/p>\r\n

Attenuation of ligand-induced activation of angiotensin II type 1 receptor signaling by the type 2 receptor via protein kinase C. T. Inuzuka, Y. Fujioka, M. Tsuda, M. Fujioka, A.O. Satoh, K. Horiuchi, S. Nishide, A. Nanbo, S. Tanaka, and Y.\u00a0Ohba<\/span>. Sci. Rep.<\/em><\/strong> 6: 21613 (2016)<\/a><\/p>\r\n

A role of the\u00a0sphingosine-1-phosphate (S1P)-S1P receptor 2 pathway in Epithelial Defense\u00a0Against Cancer (EDAC).\u00a0S. Yamamoto, Y. Yako, Y. Fujioka, M. Kajita, T. Kameyama, S. Kon, S. Ishikawa,\u00a0Y.\u00a0Ohba<\/span>, Y. Ohno, A. Kihara, and Y. Fujita.\u00a0Mol. Biol. Cell<\/em> <\/strong>\u00a027(3): 491-499 (2016)<\/p>\r\n

2015\u5e74<\/h3>\r\n

Tyr724 phosphorylation of ELMO1 by Src is involved in cell spreading and migration via Rac1 activation.Y. Makino, M. Tsuda, Y. Ohba<\/span>, H. Nishihara, H. Sawa, K. Nagashima, and S. Tanaka.\u00a0Cell Commun. Signal.<\/b><\/em> 13: 42\u00a0(2015)<\/p>\r\n

Molecular role of RNF43 in canonical and noncanonical Wnt signaling.T. Tsukiyama, A. Fukui, S. Terai, Y. Fujioka, K. Shinada, H. Takahashi, T.P. Yamaguchi, Y. Ohba<\/span>, and S. Hatakeyama.\u00a0Mol. Cell. Biol.<\/b> <\/em>35(11): 2007-2023 (2015)<\/p>\r\n

Adaptor protein CRK induces epithelial-mesenchymal transition and metastasis of bladder cancer cells through HGF\/c-Met feedback loop. R. Matsumoto, M. Tsuda, L. Wang, N. Maishi, T. Abe, T. Kimura, M. Tanino, H. Nishihara, K. Hida, Y. Ohba<\/span>, N. Shinohara, K. Nonomura, and S. Tanaka.\u00a0<\/b>Cancer Sci.\u00a0<\/b><\/em>106(6): 709-17\u00a0(2015)<\/p>\r\n

Inhibition of multidrug transporter in tumor endothelial cells enhances antiangiogenic effects of low dose metronomic paclitaxel.K. Akiyama, N. Ohga, Y. Hida, N. Maishi, Y. Ohba<\/span>, A.M. Towfik, T. Kawamoto, H. Ohmura, K. Yamada, C. Torii, M. Shindoh, and K. Hida.\u00a0Am. J. Pathol.<\/b> <\/em>185(2): 572-580 (2015)<\/p>\r\n

2014\u5e74<\/h3>\r\n

Agonist-promoted ubiquitination differentially regulates receptor trafficking of endothelin type A and type B receptors. K. Terada, T. Horinouchi, Y. Fujioka, T. Higashi, P. Nepal, M. Horiguchi, S. Karki, C.Hatate, A. Hoshi, T. Harada, Y. Mai, Y. Ohba<\/span>, and S. Miwa.\u00a0J. Biol. Chem.<\/b> <\/em>289(51): 35283-95 (2014)<\/p>\r\n

Sustained elevation of Snail promotes Glial-Mesenchymal Transition after irradiation in malignant glioma.R. Mahabir, M, Tanino, E. Aiman, L. Wang, T. Kimura, T. Itoh, Y. Ohba<\/span>, H. Nishihara, H. Shirato, M. Tsuda, and S. Tanaka.\u00a0Neuro-Oncology<\/b><\/em> 6(5): 671-685 (2014)<\/p>\r\n

Lysosomal interaction of Akt with Phafin2: a critical step in the induction of autophagy.M. Matsuda-Lennikov, F. Suizu, N. Hirata, M. Hashimoto, K. Kimura, T. Nagamine, Y. Fujioka, Y. Ohba<\/span>, T. Iwanaga, and M. Noguchi.\u00a0PLoS One<\/b><\/em> 9(1): e79795 (2014)<\/p>\r\n

2013\u5e74<\/h3>\r\n

A Ca2+<\/sup>-dependent signalling circuit regulates influenza A virus internalisation and infection.Y. Fujioka, M. Tsuda, A. Nanbo, T. Hattori, J. Sasaki, T. Sasaki, T. Miyazaki, and Y. Ohba<\/span>*.\u00a0Nat. Commun.<\/em><\/strong>\u00a04: 2763 (2013)<\/a><\/p>\r\n

\u5317\u5927\u306b\u3088\u308b\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u8a18\u4e8b<\/a>
Yahoo\u30cb\u30e5\u30fc\u30b9
\u5317\u6d77\u9053\u306e\u30cb\u30e5\u30fc\u30b9\u30fb\u6c17\u8c61\u60c5\u5831\u3001\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u30cb\u30e5\u30fc\u30b9\u5317\u6d77\u9053
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Beneficial innate signaling interference for anti-bacterial responses by a TLR-mediated enhancement of the MKP-IRF3 axis.H. Negishi, K. Matsuki, N. Endo, H. Sarashina, S. Miki, A. Matsuda,K.Fukazawa, N. Taguchi-Atarashi, H. Ikushima, H. Yanai, J. Nishio, K. Honda, Y. Fujioka, Y. Ohba<\/span>, T.Noda,S.Taniguchi, E. Nishida, Y. Zhang, H. Chi, R. A. Flavell, and T. Taniguchi.\u00a0Proc. Natl. Acad. Sci. U.S.A.<\/b><\/em> 110(49): 19884-19889 (2013)<\/p>\r\n

Inhibition of influenza A virus infection by Galectin-9.\u00a0\u00a0T. Hattori, J. Maruyama, Y. Fujioka, Y. Nakayama, Y. Ohba, T. Niki, T. Arikawa, T. Miyazaki, M. Hirashima, and H. Kida.\u00a0Jpn. J. Vet. Res.<\/em><\/strong> 61(1&2):5-18(2013)<\/p>\r\n

All members of the EPI64 subfamily of TBC\/RabGAPs also have GAP activities toward Ras.\u00a0H. Nagai, S. Yasuda, Y. Ohba, M. Fukuda, and T. Nakamura.\u00a0J. Biochem.<\/em><\/strong> 153(5): 283-288 (2013)<\/p>\r\n

2012\u5e74<\/h3>\r\n

Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1.\u00a0S. Chiba, M. Baghdadi, H. Akiba, H. Yoshiyama, I. Kinoshita, H. Dosaka-Akita, Y. Fujioka, Y. Ohba, J.V. Gorman, J.D. Colgan, M. Hirashima, T. Uede, A. Takaoka, H. Yagita and M. Jinushi.\u00a0Nat. Immunol.<\/em><\/strong>\u00a013(9): 832\u2013842 (2012)<\/p>\r\n

Simultaneous inhibition of Src and Aurora kinases by SU6656 induces therapeutic synergy in human synovial sarcoma growth, invasion, and angiogenesis\u00a0in vivo<\/em>. R. Arai, M. Tsuda*, T. Watanabe, T. Ose, C. Obuse, K. Maenaka, A. Minami and Y. Ohba.\u00a0Eur. J. Cancer<\/em><\/strong>\u00a048(15): 2417-2430 (2012)<\/p>\r\n

2011\u5e74<\/h3>\r\n

DJ-1 associates with synaptic membranes. Y.\u00a0Usami, T. Hatano, S. Imai, SI. Kubo, S. Sato, S. Saiki, Y. Fujioka, Y. Ohba, F. Sato, M. Funayama, H. Eguchi, K. Shiba, H. Ariga, J. Shen, N. Hattori.\u00a0Neurobiol. Dis.<\/em><\/strong>\u00a043(3): 651-662 (2011)<\/p>\r\n

RANKL expression specifically observed in vivo promotes epithelial mesenchymal transition and tumor progression. T. Yamada, M. Tsuda, T. Takahashi, Y. Totsuka, M. Shindoh and Y. Ohba*. Am. J. Pathol.<\/em><\/strong>\u00a0178(6): 2845-2856 (2011)<\/a><\/p>\r\n

IRF3 regulates cardiac fibrosis but not hypertrophy in mice during angiotensin II-induced hypertension.\u00a0K. Tsushima, T. Osawa, H. Yanai, A. Nakajima, A. Takaoka, I. Manabe, Y. Ohba, Y. Imai, T. Taniguchi and R. Nagai.\u00a0FASEB J.<\/em><\/strong>\u00a025(5): 1531-1543 (2011)<\/p>\r\n

The Ras\u2013PI3K Signaling Pathway Is Involved in Clathrin-Independent Endocytosis and the Internalization of Influenza Viruses.\u00a0Y.Fujioka, M. Tsuda, T. Hattori, J. Sasaki, T. Sasaki, T. Miyazaki &\u00a0Y. Ohba*. PLoS One<\/em><\/strong>\u00a06(1): e16324 (2011)<\/a>Hattori, J. Sasaki, T. Sasaki, T. Miyazaki &\u00a0Y. Ohba*. PLoS One<\/em><\/strong>\u00a06(1): e16324 (2011)<\/a><\/p>\r\n

\u5317\u5927\u306b\u3088\u308b\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u8a18\u4e8b<\/a>
Nature Asia<\/a><\/p>\r\n

Induction of Colonic Regulatory T Cells by Indigenous Clostridium<\/em> Species.\u00a0K. Atarashi, T. Tanoue, T. Shima, A. Imaoka, T. Kuwahara, Y. Momose, G. Cheng, S. Yamasaki, T. Saito, Y. Ohba, T. Taniguchi, K. Takeda, S. Hori, I.I. Ivanov, Y. Umesaki, K. Itoh & K. Honda.\u00a0Science<\/em><\/strong>\u00a0331(6015): 337-341 (2011)\u00a0<\/span><\/p>\r\n

ZAPS is a potent stimulator of RIG-I-mediated signaling for antiviral response.\u00a0S. Hayakawa, S. Shiratori, H. Yamato, T. Kameyama, C. Kitatsuji, F. Kashigi, S. Goto, S. Kameoka, D. Fujikura, T. Yamada, T. Mizutani, M. Kazumata, M. Sato, J. Tanaka, M. Imamura, M. Asaka, Y. Ohba, T. Miyazaki & A. Takaoka.\u00a0Nat. Immunol.<\/em><\/strong>\u00a012(1): 37-44 (2011)<\/p>\r\n

cover of this issue:<\/a><\/p>\r\n

2010\u5e74<\/h3>\r\n

Conversion of Helicobacter pylori CagA from senescence inducer to oncogenic driver through polarity-dependent regulation of p21.\u00a0Y. Saito, N. Murata-Kamiya, Y. Ohba & M. Hatakeyama.\u00a0J. Exp. Med.<\/em><\/strong> 207(10): 2157-2174 (2010)<\/p>\r\n

A novel FRET-based biosensor for the measurement of BCR-ABL activity and its response to drugs in living cells.\u00a0T. Mizutani, T. Kondo, S. Darmanin, M. Tsuda, S. Tanaka, M. Tobiume, M. Asaka, & Y. Ohba*.\u00a0Clin. Cancer Res.<\/em><\/strong> 16(15): 3964-3975 (2010)<\/a><\/p>\r\n

\u00a0Commentary on this paper:\u00a0Clin. Cancer Res. 16(15): 3822-3824 (2010)<\/a><\/p>\r\n

2009\u5e74<\/h3>\r\n

Increased motility and invasiveness of tumor cells that survived 10 Gy irradiation. K. Tsutsumi, M. Tsuda, N. Yazawa, H. Nakamura, S. Ishihara, H. Haga, M. Yasuda, R. Yamazaki, H. Shirato,H. Kawaguchi, T. Nishioka, Y. Ohba. Cell Struct. Funct.<\/em><\/strong> 34(2): 89-96 (2010)<\/p>\r\n

The adaptor protein Crk induces Src-dependent activation of p38 MAPK in regulation of synovial sarcoma cell proliferation. T. Watanabe, M. Tsuda, S. Tanaka, Y. Ohba, H. Kawaguchi, T. Majima, H. Sawa, & A. Minami. Mol. Cancer Res.<\/em><\/strong> 7(9): 1582-1592 (2009)<\/p>\r\n

Visualization of Ras-PI3K interaction in the endosome using BiFC. K. Tsutsumi, Y. Fujioka, M. Tsuda,H. Kawaguchi, Y. Ohba*. Cell Signal.<\/em><\/strong> 21(11): 1672-1679 (2009)<\/a><\/p>\r\n

Helicobacter pylori CagA causes mitotic impairment and induces chromosomal instability. M. Umeda, N. Murata-Kamiya, Y. Saito, Y. Ohba, M. Takahashi, & M. Hatakeyama. J. Biol. Chem.<\/em><\/strong> 284(33): 22166-22172 (2009)<\/p>\r\n

Parkin stabilizes PINK1 through direct interaction. K. Shiba, T. Arai, S. Sato, SI. Kubo, Y. Ohba, Y. Mizuno, & N. Hattori. Biochem. Biophys. Res. Commun.<\/em><\/strong> 583(3): 331-335 (2009)<\/p>\r\n

Integral role of transcription factor 8 in the negative regulation of tumor angiogenesis.\u00a0T. Inuzuka, M. Tsuda, H. Kawaguchi, Y. Higashi, & Y. Ohba*.\u00a0Cancer Res.<\/em><\/strong> 69(4): 1678-1684 (2009)<\/a><\/p>\r\n

Transcription factor 8 activates R-Ras to regulate angiogenesis.\u00a0T. Inuzuka, M. Tsuda, H. Kawaguchi, & Y. Ohba*\u00a0Biochem. Biophys. Res. Commun.<\/em><\/strong> 379(2): 510-513 (2009)<\/p>\r\n

2008\u5e74<\/h3>\r\n

Clinicopathological significance of expression of p-c-Jun, TCF4 and beta-Catenin in colorectal tumors.\u00a0K. Takeda, I. Kinoshita, Y. Shimizu, Y. Ohba, T. Itoh, Y. Matsuno, & H. Dosaka-Akita.\u00a0BMC-Cancer<\/em><\/strong> 8: 328 (2008)<\/p>\r\n

PTHrP promotes malignancy of human oral cancer cell downstream of the EGFR signaling.\u00a0T. Yamada, M. Tsuda, Y. Ohba*, H. Kawaguchi, Y. Totsuka, & M. Shindoh.\u00a0Biochem. Biophys. Res. Commun.<\/em><\/strong> 368(3): 575-581 (2008)<\/p>\r\n

Homeostatic erythropoiesis by the transcription factor IRF2 through attenuation of type I interferon signaling.\u00a0T. Mizutani, K. Tsuji, Y. Ebihara, S. Taki, Y. Ohba, T. Taniguchi, & K. Honda.\u00a0Exp. Hematol.<\/em><\/strong> 36(3): 255-264 (2008)<\/p>\r\n

2007\u5e74<\/h3>\r\n

OLIG2 inhibits the motility of a human glial tumor cell line by activating RhoA.\u00a0K. Tabu, Y. Ohba, T. Suzuki, Y. Makino, T. Kimura, A. Ohnishi, M. Sakai, T. Watanabe, S. Tanaka &\u00a0H. Sawa. Mol. Cancer Res.<\/em><\/strong> 5(10): 1099-1109 (2007)<\/p>\r\n

DAI (DLM1\/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response.\u00a0A. Takaoka, Z. C. Wang, M. K. Choi, H. Yanai, H. Negishi, T. Ban, M. Miyagishi, K. Honda, Y. Ohba &\u00a0T. Taniguchi.\u00a0Nature<\/em><\/strong> 448(7152): 501-505 (2007)<\/p>\r\n

Spatiotemporal mobilization of Toll\/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA.\u00a0K. Funami, M. Sasai, Y. Ohba, H. Oshiumi, T. Seya & M. Matsumoto.\u00a0J. Immunol.<\/em><\/strong> 179(10): 6867-6872 (2007)<\/p>\r\n

Location of possible miRNA processing site in SmD3\/SmB nuclear bodies in Arabidopsis.\u00a0Y. Fujioka, M. Utsumi, Y. Ohba & Y. Watanabe.\u00a0Plant Cell Physiol.<\/em><\/strong> 48(9): 1243-1253 (2007)<\/p>\r\n

Differential Ras activation between caveolae\/raft and non-raft microdomains.\u00a0T. Fukano, A. Sawano, Y. Ohba, M. Matsuda, & A. Miyawaki.\u00a0Cell Struct. Funct.<\/em><\/strong> 32(1):9-15 (2007).<\/p>\r\n

2006\u5e74<\/h3>\r\n

Differential contribution of Puma and Noxa in dual regulation of p53-mediated apoptotic pathways.\u00a0T. Shibue, S. Suzuki, H. Okamoto, H. Yoshida, Y. Ohba, A. Takaoka & T. Taniguchi.\u00a0EMBO J.<\/em><\/strong> 25(20): 4952-62 (2006)<\/p>\r\n

Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program.\u00a0H. Negishi, Y. Fujita, H. Yanai, S. Sakaguchi, X. Ouyang, M. Shinohara, H. Takayanagi, Y. Ohba T. Taniguchi, & K. Honda.\u00a0Proc. Natl. Acad. Sci. USA<\/em><\/strong> 103(41): 15136-15141 (2006)<\/p>\r\n

2005\u5e74\u4ee5\u524d<\/h3>\r\n

\u3000\u6771\u4eac\u5927\u5b66\uff08\u8c37\u53e3\u7814\uff09<\/h4>\r\n

Negative regulation of Toll-like receptor signaling by IRF-4.<\/span>\u00a0<\/em><\/strong>H. Negishi\u2020, Y. Ohba\u2020, H. Yanai, A. Takaoka, K. Honma, K. Yui, T. Matsuyama, T. Taniguchi & K. Honda.\u00a0<\/span>Proc. Natl Acad. Sci. U.S.A<\/em><\/strong>.<\/strong><\/em> 102: 15989-15994 (2005) [\u2020, equal contribution]<\/span><\/p>\r\n

Spatiotemporal regulation of MyD88-IRF-7 signalling pathway for robust type-I interferon induction.\u00a0<\/em><\/strong>K. Honda\u2020, Y. Ohba\u2020, H. Yanai\u2020, H. Negishi, T. Mizutani, A. Takaoka, C. Taya & T. Taniguchi.\u00a0Nature<\/em><\/strong> 434(7036): 1035-1040 (2005) [\u2020, equal contribution]<\/p>\r\n

IRF-7 is the master regulator of type-1 interferon-dependent immune responses.\u00a0K. Honda, H. Yanai, H. Negishi, T. Mizutani, M. Asagiri, M. Sato, N. Shimada, Y. Ohba, A. Takaoka, N. Yoshida & T. Taniguchi.\u00a0Nature<\/em><\/strong> 434(7034): 772-777 (2005)<\/p>\r\n

Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors.\u00a0A. Takaoka, H. Yanai, S. Kondo, G. Duncan, H. Negishi, T. Mizutani, S. Kano, K. Honda, Y. Ohba, T. Mak & T. Taniguchi.\u00a0Nature<\/em><\/strong> 434(7030): 243-249 (2005)<\/p>\r\n

Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling.\u00a0<\/em><\/strong>K. Honda, H. Yanai, T. Mizutani, H. Negishi, N. Shimada, N. Suzuki, Y. Ohba, A. Takaoka, W. C. Yeh & T. Taniguchi.\u00a0Proc. Natl. Acad. Sci. U.S.A.<\/em><\/strong>101(43): 15416-15421 (2004)<\/p>\r\n

\u3000\u5927\u962a\u5927\u5b66\uff08\u677e\u7530\u7814\uff09<\/h4>\r\n

STAT3 noncell-autonomously controls planar cell polarity during zebrafish convergence and extension.\u00a0C. Miyagi, S. Yamashita, Y. Ohba, H. Yoshizaki, M. Matsuda & T. Hirano.\u00a0J. Cell Biol.<\/em> <\/strong>166(7): 975-981 (2004)<\/p>\r\n

Cell Type-specific Regulation of RhoA Activity during Cytokinesis.\u00a0<\/em><\/strong>H. Yoshizaki, Y. Ohba, M.C. Parrini, N. G. Dulyaninova, A. R. Bresnick, N. Mochizuki & M. Matsuda.\u00a0J. Biol. Chem.<\/em><\/strong> 279(43): 44756-44762 (2004)<\/p>\r\n

RalA Activation at Nascent Lamellipodia of EGF-stimulated Cos7 cells and Migrating MDCK Cells.\u00a0A. Takaya, Y. Ohba, K. Kurokawa & M. Matsuda.\u00a0Mol. Biol. Cell<\/em><\/strong> 15(6): 2549-2557 (2004)<\/p>\r\n

Co-activation of Rac1 and Cdc42 at Lamellipodia and Membrane Ruffles Induced by Epidermal Growth Factor.\u00a0K. Kurokawa, R. E. Itoh, H. Yoshizaki, Y. Ohba, T. Nakamura & M. Matsuda.\u00a0Mol. Biol. Cell<\/em><\/strong> 15(3): 1003-1010 (2004)<\/p>\r\n

Activity of Rho-family GTPases during cell division as visualized with FRET-based probes.\u00a0H. Yoshizaki, Y. Ohba, K. Kurokawa, R. E. Itoh, T. Nakamura, N. Mochizuki, K. Nagashima & M. Matsuda.\u00a0J. Cell Biol. <\/em><\/strong>162(2): 223-232 (2003)<\/p>\r\n

Mechanism of the spatio-temporal regulation of Ras and Rap1.\u00a0Y. Ohba, K. Kurokawa & M. Matsuda.\u00a0EMBO J<\/em><\/strong>.<\/strong><\/em> 22(4): 859-869 (2003)<\/p>\r\n

Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway-mediated Rap1 activation.\u00a0A. Sakakibara, Y. Ohba, K. Kurokawa, M. Matsuda & S. Hattori.\u00a0J. Cell Sci.<\/em><\/strong> 115(Pt 24): 4915-4924 (2002)<\/p>\r\n

Activation of rac and cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cells.\u00a0R. E. Itoh, K. Kurokawa, Y. Ohba, H. Yoshizaki, N. Mochizuki & M. Matsuda.\u00a0Mol. Cell. Biol.<\/em><\/strong> 22(18): 6582-6591 (2002)<\/p>\r\n

Spatio-temporal images of growth-factor-induced activation of Ras and Rap1.\u00a0N. Mochizuki, S. Yamashita, K. Kurokawa, Y. Ohba, T. Nagai, A. Miyawaki & M. Matsuda.\u00a0Nature <\/em><\/strong>411(6841): 1065-1068 (2001)<\/p>\r\n

A pair of fluorescent resonance energy transfer-based probes for tyrosine phosphorylation of the CrkII adaptor protein in vivo.\u00a0<\/em><\/strong>K. Kurokawa, N. Mochizuki, Y. Ohba, H. Mizuno, A. Miyawaki & M. Matsuda.\u00a0J. Biol. Chem. <\/em><\/strong>276(33): 31305-31310 (2001)<\/p>\r\n

\u3000\u56fd\u7acb\u56fd\u969b\u533b\u7642\u30bb\u30f3\u30bf\u30fc\uff08\u677e\u7530\u7814\uff09<\/h4>\r\n

Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis.\u00a0Y. Ohba, K. Ikuta, A. Ogura, J. Matsuda, N. Mochizuki, K. Nagashima, K. Kurokawa, B. J. Mayer, K. Maki, J. Miyazaki & M. Matsuda.\u00a0EMBO J.<\/em><\/strong> 20(13): 3333-3341 (2001)<\/p>\r\n

Rap2 as a slowly responding molecular switch in the rap1 signaling cascade.\u00a0Y. Ohba, N. Mochizuki, K. Matsuo, S. Yamashita, M. Nakaya, Y. Hashimoto, M. Hamaguchi, T. Kurata, K. Nagashima & M. Matsuda.\u00a0Mol. Cell. Biol.<\/em><\/strong> 20(16): 6074-6083 (2000)<\/p>\r\n

CalDAG-GEFIII Activation of Ras, R-Ras and Rap1.\u00a0<\/em><\/strong>S. Yamashita, N. Mochizuki, Y. Ohba, M. Tobiume, Y. Okada, H. Sawa, K. Nagashima and M. Matsuda.\u00a0J. Biol. Chem.<\/em><\/strong> 275(33): 25488-25493 (2000)<\/p>\r\n

Regulatory proteins of R-Ras, TC21\/R-Ras2, and M-Ras\/R-Ras3.\u00a0Y. Ohba, N. Mochizuki, S. Yamashita, A. M. Chan, J. W. Schrader, S. Hattori, K. Nagashima & M. Matsuda.\u00a0J. Biol. Chem.<\/em><\/strong> 275(26): 20020-20026 (2000)<\/p>\r\n

Crk Activation of JNK via C3G and R-Ras.\u00a0N. Mochizuki, Y. Ohba, S. Kobayashi, N. Otsuka, A. M. Graybiel, S. Tanaka & M. Matsuda.\u00a0J. Biol. Chem.<\/em><\/strong> 275(17): 12667-12671 (2000)<\/p>\r\n

Activation of the ERK\/MAPK pathway by an isoform of rap1GAP associated with Gai.\u00a0N. Mochizuki, Y. Ohba, E. Kiyokawa, T. Kurata, T. Murakami, T. Ozaki, A. Kitabatake, K. Nagashima & M. Matsud. \u00a0Nature<\/em><\/strong> 400(6747): 891-4 (1999)<\/p>\r\n

\u3000\u5317\u6d77\u9053\u5927\u5b66\uff08\u9577\u5d8b\u7814\uff09<\/h4>\r\n

Eosinophilic inclusions in ependymoma represent microlumina: a light and electron microscopic study.\u00a0N. Kawano, Y. Ohba & K. Nagashima.\u00a0Acta Neuropathol.<\/em><\/strong> 99(2): 214-218 (2000)<\/p>\r\n

Melanotic peritoneal sarcomatosis originating from clear cell sarcoma.\u00a0Y. Ohba, H. Suzuki, H. Hiraga, T. Ito, H. Sawa, M. Nagai, S.I. Satoh, H. Iwaki & K. Nagashima.\u00a0Pathol. Int.<\/em><\/strong> 49(7): 653-657 (1999)<\/p>\r\n

\u82f1\u6587\u7dcf\u8aac<\/h2>\r\n

Fluorescence bioimaging of intracellular signaling and its clinical application. Y. Ohba and Y. Fujioka. J. Oral Biosci.<\/strong><\/em> 58(4): 113\u2013119 (2016)<\/p>\r\n

Fluorescent protein-based biosensors to visualize signal transduction beneath the plasma membrane.Y. Fujioka, A. Nanbo, S.Y. Nishide and Y. Ohba Anal. Sci.<\/em><\/strong>\u00a031(4): 267-274 (2015)<\/p>\r\n

\u548c\u6587\u7dcf\u8aac\u7b49<\/h2>\r\n

\u5f31\u3044\u76f8\u4e92\u4f5c\u7528\u306e\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30fc\u30b9\u3068\u7d30\u80de\u5fdc\u7b54\u306e\u540c\u6642\u53ef\u8996\u5316\u3092\u5b9f\u73fe\u3059\u308b\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u6280\u8853. \u5409\u7530\u85cd\u5b50, \u85e4\u5ca1\u5bb9\u4e00\u6717, \u5929\u91ce\u9ebb\u7a42, \u5927\u5834\u96c4\u4ecb.\u3000Drug Delivery System<\/strong> 37<\/a>:102-111 (2022)\u3000<\/p>\r\n

\u30a6\u30a4\u30eb\u30b9\u306e\u7d30\u80de\u4fb5\u5165\u3092\u8996\u308b. \u85e4\u5ca1\u5bb9\u4e00\u6717, \u5929\u91ce\u9ebb\u7a42, \u5927\u5834\u96c4\u4ecb. \u533b\u5b66\u306e\u3042\u3086\u307f<\/strong> 280(9)<\/a>: 922-925 (2022) <\/p>\r\n

\u5bbf\u4e3b\u306b\u304a\u3051\u308b\u75c5\u539f\u4f53\u306e\u30c0\u30a4\u30ca\u30df\u30af\u30b9. \u85e4\u5ca1\u5bb9\u4e00\u6717, \u5929\u91ce\u9ebb\u7a42, \u5927\u5834\u96c4\u4ecb.\u3000\u5b9f\u9a13\u533b\u5b66\u5897\u520a<\/strong> 39(2)<\/a>:129 (2021) <\/p>\r\n

\u5c11\u6570\u306e\u8981\u7d20\u3092\u8a08\u6e2c\u3059\u308b\u2015\u30a6\u30a4\u30eb\u30b9\u4f55\u500b\u3067\u201c\u611f\u67d3\u201d\u3059\u308b\u304b\uff1f. \u85e4\u5ca1\u5bb9\u4e00\u6717, \u7530\u7aef\u548c\u4ec1, \u5927\u5834\u96c4\u4ecb, \u91ce\u5730\u535a\u884c. \u5b9f\u9a13\u533b\u5b66<\/strong> 35<\/a>: 3197\u20133203 (2017)<\/p>\r\n

Ras-PI3K\u30b7\u30b0\u30ca\u30eb\u306b\u3088\u308b\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u3068\u30a6\u30a4\u30eb\u30b9\u7c92\u5b50\u53d6\u308a\u8fbc\u307f\u306e\u5236\u5fa1\u6a5f\u69cb. \u85e4\u5ca1\u5bb9\u4e00\u6717, \u5927\u5834\u96c4\u4ecb. \u751f\u5316\u5b66<\/strong> 87(1)<\/a>: 91-100 (2015)<\/p>\r\n

\uff3b\u7279\u96c6\uff3d\u7d30\u80de\u306e\u5c11\u6570\u5236\u3068\u591a\u69d8\u6027\u306b\u6311\u3080\u30b7\u30f3\u30b0\u30eb\u30bb\u30eb\u30a2\u30ca\u30ea\u30b7\u30b9\u2015\u60a3\u8005\u8840\u6db2\u3068FRET\u30d0\u30a4\u30aa\u30bb\u30f3\u30b5\u30fc\u3092\u7528\u3044\u305f\u85ac\u52b9\u52b9\u679c\u4e88\u6e2c. \u5927\u5834\u96c4\u4ecb. \u751f\u4f53\u306e\u79d1\u5b66<\/strong>\uff08\u91d1\u539f\u51fa\u7248\uff0965(2): 171-175 (2014)<\/p>\r\n

FRET\u3092\u7528\u3044\u305f\u5206\u5b50\u6a19\u7684\u6cbb\u7642\u85ac\u306e\u8010\u6027\u5224\u5b9a\u6280\u8853. \u5927\u5834\u96c4\u4ecb, \u6d25\u7530\u771f\u5bff\u7f8e. \u751f\u5316\u5b66<\/strong> 84(5): 359-365 (2012)<\/p>\r\n

\u5b9f\u9a13\u6280\u8853\uff1a\u86cd\u5149\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u7528\u3044\u305f\u7d30\u80de\u5185\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u53ef\u8996\u5316. \u5927\u5834\u96c4\u4ecb, \u6d25\u7530\u771f\u5bff\u7f8e. \u65e5\u85ac\u7406\u8a8c<\/strong> 138: 271-275 (2011)<\/p>\r\n

\u86cd\u5149\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u7528\u3044\u305f\u767d\u8840\u75c5\u5206\u5b50\u6a19\u7684\u6cbb\u7642\u85ac\u306e\u52b9\u679c\u5224\u5b9a\u6280\u8853. \u5927\u5834\u96c4\u4ecb.\u3000\u30d0\u30a4\u30aa\u30a4\u30f3\u30c0\u30b9\u30c8\u30ea\u30fc<\/strong> 28(2): 33-39(2011)<\/p>\r\n

\u30d0\u30a4\u30aa\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306e\u57fa\u790e\u3068\u5fdc\u7528. \u6d25\u7530\u771f\u5bff\u7f8e, \u5927\u5834\u96c4\u4ecb.\u3000\u7d30\u80de<\/strong> 41(11): 462-463 (2009)<\/p>\r\n

\u7d30\u80de\u5185\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u53ef\u8996\u5316\u3068\u305d\u306e\u5275\u85ac\u3078\u306e\u5fdc\u7528. \u5927\u5834\u96c4\u4ecb, \u6d25\u7530\u771f\u5bff.\u3000\u5b9f\u9a13\u533b\u5b66<\/strong>\uff08\u5897\u520a\u53f7\uff09 6: 2506-2513 (2008)<\/p>\r\n

\u7d30\u80de\u5897\u6b96\u3068\u7d30\u80de\u6b7b\uff1a\u5927\u5834\u96c4\u4ecb, \u677e\u7530\u9053\u884c\u3000\u75c5\u7406\u3068\u81e8\u5e8a<\/strong>\uff08\u81e8\u6642\u5897\u520a\u53f7\uff0922: 75-80 (2004)<\/p>\r\n

\u304c\u3093\u907a\u4f1d\u5b50\u7523\u7269Ras\u306e\u60c5\u5831\u4f1d\u9054\u3068\u305d\u306e\u53ef\u8996\u5316\uff1a\u5927\u5834\u96c4\u4ecb, \u677e\u7530\u9053\u884c\u3000\u751f\u5316\u5b66<\/strong> 76: 16-28 (2004)<\/p>\r\n

\u751f\u304d\u305f\u7d30\u80de\u3092\u4f7f\u3063\u305f\u764c\u907a\u4f1d\u5b50\u7814\u7a76\u2015\u305d\u306e\u65b0\u3057\u3044\u52d5\u304d\uff1a\u5927\u5834\u96c4\u4ecb\u3000\u533b\u5b66\u306e\u3042\u3086\u307f<\/strong> 203: 248-250 (2002)<\/p>\r\n

\u4e09\u91cf\u4f53G\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u3088\u308b\u4f4e\u5206\u5b50\u91cfG\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6d3b\u6027\u5316\u6a5f\u69cb\u3068MAP\u30ad\u30ca\u30fc\u30bc\u306e\u6d3b\u6027\u5316\uff1a\u5927\u5834\u96c4\u4ecb, \u671b\u6708\u76f4\u6a39, \u677e\u7530\u9053\u884c\u3000\u5b9f\u9a13\u533b\u5b66<\/strong> 18: 1373-1378 (2000)<\/p>\r\n

Ras\/Rap1\/Rho\uff1a\u5927\u5834\u96c4\u4ecb, \u677e\u7530\u9053\u884c\u3000Bio Science \u65b0\u7528\u8a9e\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u514d\u75ab<\/strong>\uff3b\u7b2c\uff12\u7248\uff3d\uff08\u6589\u85e4\u9686\uff0c\u7af9\u68ee\u5229\u5fe0\u7de8\uff09\u7f8a\u571f\u793e\u6771\u4eac: 126-127 (2000)<\/p>\r\n

\u810a\u9ac4\u816b\u760d (3) \u9ac4\u819c\u816b\uff1a\u5927\u5834\u96c4\u4ecb, \u9577\u5d8b\u548c\u90ce\u3000Clinical Neuroscience<\/strong> 15: 12-13 (1997)<\/p>\r\n","protected":false},"excerpt":{"rendered":"

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