英文原著論文

2020年

Calcium Wave Promotes Cell Extrusion. Takeuchi Y, Narumi R, Akiyama R, Vitiello E, Shirai T, Tanimura N, Kuromiya K, Ishikawa S, Kajita M, Tada M, Harada Y, Akieda Y, Ishitani T, Fujioka Y, Y. Ohba, Yamada S, Hosokawa Y, Toyama Y, Matsui T, Fujita Y. Curr Biol.30:670-681, e6, 2020

2019年

Localization of BCR-ABL to stress granules contributes to its oncogenic function. Kashiwagi S, Fujioka Y, Kondo T, Satoh AO, Yoshida A, Fujioka M, Sasajima H, Amano M, Teshima T and Ohba YCell Struct. Funct. 44: 195-204, 2019

Folding latency of fluorescent proteins affects the mitochondrial localization of fusion proteins. Kashiwagi S, Fujioka Y, Satoh AO, Yoshida A, Fujioka M, Nepal P, Tsuzuki A, Aoki O, Paudel S, Sasajima H and Ohba Y. Cell Struct. Funct. 44: 183-194, 2019

Antibody-free digital influenza virus counting based on neuraminidase activity. Tabata VT, Minagawa Y, Kawaguchi Y, Ono M, Moriizumi Y, Yamayoshi S, Fujioka Y, Ohba Y, Kawaoka Y & Noji H. Sci. Rep. 9: 1067, 2019  

Development of immortalized human tumor endothelial cells from renal cancer. Maishi N, Kikuchi H, Sato M, Nagao-Kitamoto H, Annan DA, Baba S, Hojo T, Yanagiya M, Ohba Y, Ishii G, Masutomi K, Shinohara N, Hida Y and Hida K. Int. J. Mol. Sci. 20: pii: E4595, 2019

Clinical efficacy and safety of first-line nilotinib therapy and evaluation of the clinical utility of the FRET-based drug sensitivity test. Kondo T, Fujioka M, Fujisawa S, Sato K, Tsuda M, Miyagishima T, Mori A, Iwasaki H, Kakinoki Y, Yamamoto S, Haseyama Y, Ando S, Shindo M, Ota S, Kurosawa M, Ohba Y, Teshima T; North Japan Hematology Study Group (NJHSG). Int. J. Hematol. 110: 482-489, 2019

A peptide derived from phosphoinositide 3-kinase inhibits endocytosis and influenza virus infection. Fujioka Y, Satoh AO, Horiuchi K, Fujioka M, Tsutsumi M, Sasaki J, Nepal P, Kashiwagi S, Paudel S, Nishide S, Nanbo A, Sasaki T and Ohba Y.Cell Struct. Funct. 44: 61-74, 2019

2018年

Budding of Ebola Virus Particles Requires the Rab11-Dependent Endocytic Recycling Pathway. A. Nanbo and Y. Ohba. J. Infect. Dis.218(suppl_5): S388–S396, 2018

Infection of Epstein-Barr virus in type III latency modulates biogenesis of exosomes and the expression profile of exosomal miRNAs in the Burkitt lymphoma Mutu cell lines. A. Nanbo, H. Katano, M. Kataoka, S. Hoshina, T. Sekizuka, M. Kuroda and Y. Ohba. Cancer 10(7): 237, 2018

A Sialylated Voltage-Dependent Ca2+Channel Binds Hemagglutinin and Mediates Influenza A Virus Entry into Mammalian Cells. Y. Fujioka, S. Nishide, T. Ose, T. Suzuki, I. Kato, H. Fukuhara, M. Fujioka, K. Horiuchi, A. O. Satoh, P. Nepal, S. Kashiwagi, J. Wang, M. Horiguchi, Y. Sato, S. Paudel, A. Nanbo, T. Miyazaki, H. Hasegawa, K. Maenaka and Y. OhbaCell Host Microbe 23(6): 809-818 (2018)

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The role of transforming growth factor β in cell-to-cell contact-mediated Epstein-Barr virus transmission. A. Nanbo, M. Ohashi, H. Yoshiyama and Y. OhbaFront. Microbiol. 9: 984 (2018)

Pretreatment evaluation of fluorescence resonance energy transfer‐based drug sensitivity test for patients with chronic myelogenous leukemia treated with dasatinib.T. Kondo, M. Fujioka, M. Tsuda, K. Murai, K. Yamaguchi, T. Miyagishima, M. Shindo, T. Nagashima, K. Wakasa, N. Fujimoto, S. Yamamoto, M. Yonezumi, S. Saito, S. Sato, K. Ogawa, T. Chou, R. Watanabe, Y. Kato, S. Takahashi, Y. Okano, J. Yamamoto, M. Ohta, H. Iijima, K. Oba, S. Kishino, J. Sakamoto, Y. Ishida, Y. Ohba and T. Teshima. Cancer Sci. 109: 2256-2265 (2018)

Epstein-Barr Virus Acquires Its Final Envelope on Intracellular Compartments With Golgi Markers. A. Nanbo, T. Noda and Y. Ohba. Front. Microbiol. 9: 454 (2018)

Dermoscopic evaluation for skin grafts after surgery; neo-vascularization correlates with survival of skin grafts: a prospective study. S. Kitamura, T. Yanagi, Y. Inamura-Takashima, K. Imafuku, H. Hata, Y. Fujioka, Y. Ohba and H. Shimizu. J. Dermatol. Sci. 90: 213-216 (2018)

Ebola virus requires a host scramblase for externalization of phosphatidylserine on the surface of viral particles. A. Nanbo, J. Maruyama, M. Imai, M. Ujie, Y. Fujioka, S. Nishide, A. Takada, Y. Ohba and Y. Kawaoka. PLoS Pathog. 14(1): e1006848 (2018)

2017年

Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes. S. Kon, K. Ishibashi, H. Katoh, S. Kitamoto, T. Shirai, S. Tanaka, M. Kajita, S. Ishikawa, H. Yamauchi, Y. Yako, T. Kamasaki, T. Matsumoto, H. Watanabe, R. Egami, A. Sasaki, A. Nishikawa, I. Kameda, T. Maruyama, R. Narumi, T. Morita, Y. Sasaki, R. Enoki, S. Honma, H. Imamura, M. Oshima, T. Soga, J.I. Miyazaki, M.R. Duchen, J.M. Nam, Y. Onodera, S. Yoshioka, J. Kikuta, M. Ishii, M. Imajo, E. Nishida, Y. Fujioka, Y. Ohba, T. Sato and Y. Fujita. Nat. Cell Biol. 9(5): 530-541 (2017)

Improved FRET biosensor for the measurement of BCR-ABL activity in chronic myeloid leukemia cells. M. Horiguchi, M. Fujioka, T. Kondo, Y. Fujioka, X. Li, K. Horiuchi, A.O. Satoh, P. Nepal, S. Nishide, A. Nanbo, T. Teshima and Y. Ohba. Cell. Struct. Funct. 42(1): 15-26 (2017)

Rab5-regulated endocytosis plays a crucial role in apical extrusion of transformed cells. S. Saitoh, T. Maruyama, Y. Yako, M. Kajita, Y. Fujioka, Y. Ohba, N. Kasai, N. Sugama, S. Kon, S. Ishikawa, T. Hayashi, T. Yamazaki, M. Tada and Y. Fujita. Proc. Natl. Acad. Sci. U.S.A. 114(12): E2327-E2336 (2017)

A leukemogenic kinase, FIP1L1-PDGFRA, and a SUMO E3 ligase, PIAS1, form a positive crosstalk via their enzymatic activities. M. Ibata, J. Iwasaki, Y. Fujioka, K. Nakagawa, S. Darmanin, M. Onozawa, D. Hashimoto, Y. Ohba, S. Hatakeyama, T. Teshima and T. Kondo. Cancer Sci. 108(2): 200-207, (2017)

2016年

Epstein-Barr virus exploits host endocytic machinery for cell-to-cell viral transmission rather than a virological synapse. A. Nanbo, K. Kachi, H. Yoshiyama and Y. Ohba. J. Gen. Virol. 97(11): 2989-3006 (2016)

Tumour endothelial cells in high metastatic tumours promote metastasis via epigenetic dysregulation of biglycan. N. Maishi, Y. Ohba, K. Akiyama, N. Ohga, J.I. Hamada, H. Nagao-Kitamoto, M. Alam, K. Yamamoto, T. Kawamoto, N. Inoue, A. Taketomi, M. Shindoh, Y. Hida and K. Hida. Sci. Rep. 6: 28039 (2016)

Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia. R. Okumura, T. Kurakawa, T. Nakano, H. Kayama, M. Kinoshita, D. Motooka, K. Gotoh, T. Kimura, N. Kamiyama, T. Kusu, Y. Ueda, H. Wu, H. Iijima, S. Barman, H. Osawa, H. Matsuno, J. Nishimura, Y. Ohba, S. Nakamura, T. Iida, M. Yamamoto, E. Umemoto, K. Sano and K. Takeda. Nature 532(7597): 117-121 (2016)

Receptor activator of NF-κB ligand induces cell adhesion and integrin α2 expression via NF-κB in head and neck cancers. T. Yamada, M. Tsuda, T. Wagatsuma, Y. Fujioka, M. Fujioka, A.O. Satoh, K. Horiuchi, S. Nishide, A. Nanbo, Y. Totsuka, H. Haga, S. Tanaka, M. Shindoh, and Y. Ohba. Sci. Rep. 6: 23545 (2016)

Attenuation of ligand-induced activation of angiotensin II type 1 receptor signaling by the type 2 receptor via protein kinase C. T. Inuzuka, Y. Fujioka, M. Tsuda, M. Fujioka, A.O. Satoh, K. Horiuchi, S. Nishide, A. Nanbo, S. Tanaka, and Y. Ohba. Sci. Rep. 6: 21613 (2016)

A role of the sphingosine-1-phosphate (S1P)-S1P receptor 2 pathway in Epithelial Defense Against Cancer (EDAC). S. Yamamoto, Y. Yako, Y. Fujioka, M. Kajita, T. Kameyama, S. Kon, S. Ishikawa, Y. Ohba, Y. Ohno, A. Kihara, and Y. Fujita. Mol. Biol. Cell  27(3): 491-499 (2016)

2015年

Tyr724 phosphorylation of ELMO1 by Src is involved in cell spreading and migration via Rac1 activation.Y. Makino, M. Tsuda, Y. Ohba, H. Nishihara, H. Sawa, K. Nagashima, and S. Tanaka. Cell Commun. Signal. 13: 42 (2015)

Molecular role of RNF43 in canonical and noncanonical Wnt signaling.T. Tsukiyama, A. Fukui, S. Terai, Y. Fujioka, K. Shinada, H. Takahashi, T.P. Yamaguchi, Y. Ohba, and S. HatakeyamaMol. Cell. Biol. 35(11): 2007-2023 (2015)

Adaptor protein CRK induces epithelial-mesenchymal transition and metastasis of bladder cancer cells through HGF/c-Met feedback loop. R. Matsumoto, M. Tsuda, L. Wang, N. Maishi, T. Abe, T. Kimura, M. Tanino, H. Nishihara, K. Hida, Y. Ohba, N. Shinohara, K. Nonomura, and S. Tanaka. Cancer Sci. 106(6): 709-17 (2015)

Inhibition of multidrug transporter in tumor endothelial cells enhances antiangiogenic effects of low dose metronomic paclitaxel.K. Akiyama, N. Ohga, Y. Hida, N. Maishi, Y. Ohba, A.M. Towfik, T. Kawamoto, H. Ohmura, K. Yamada, C. Torii, M. Shindoh, and K. HidaAm. J. Pathol. 185(2): 572-580 (2015)

2014年

Agonist-promoted ubiquitination differentially regulates receptor trafficking of endothelin type A and type B receptors. K. Terada, T. Horinouchi, Y. Fujioka, T. Higashi, P. Nepal, M. Horiguchi, S. Karki, C.Hatate, A. Hoshi, T. Harada, Y. Mai, Y. Ohba, and S. Miwa. J. Biol. Chem. 289(51): 35283-95 (2014)

Sustained elevation of Snail promotes Glial-Mesenchymal Transition after irradiation in malignant glioma.R. Mahabir, M, Tanino, E. Aiman, L. Wang, T. Kimura, T. Itoh, Y. Ohba, H. Nishihara, H. Shirato, M. Tsuda, and S. Tanaka. Neuro-Oncology 6(5): 671-685 (2014)

Lysosomal interaction of Akt with Phafin2: a critical step in the induction of autophagy.M. Matsuda-Lennikov, F. Suizu, N. Hirata, M. Hashimoto, K. Kimura, T. Nagamine, Y. Fujioka, Y. Ohba, T. Iwanaga, and M. Noguchi. PLoS One 9(1): e79795 (2014)

2013年

A Ca2+-dependent signalling circuit regulates influenza A virus internalisation and infection.Y. Fujioka, M. Tsuda, A. Nanbo, T. Hattori, J. Sasaki, T. Sasaki, T. Miyazaki, and Y. Ohba*. Nat. Commun. 4: 2763 (2013)

北大によるプレスリリース記事
Yahooニュース
北海道のニュース・気象情報、ネットワークニュース北海道
(ともにNHK、11/14)

Beneficial innate signaling interference for anti-bacterial responses by a TLR-mediated enhancement of the MKP-IRF3 axis.H. Negishi, K. Matsuki, N. Endo, H. Sarashina, S. Miki, A. Matsuda,K.Fukazawa, N. Taguchi-Atarashi, H. Ikushima, H. Yanai, J. Nishio, K. Honda, Y. Fujioka, Y. Ohba, T.Noda,S.Taniguchi, E. Nishida, Y. Zhang, H. Chi, R. A. Flavell, and T. Taniguchi. Proc. Natl. Acad. Sci. U.S.A. 110(49): 19884-19889 (2013)

Inhibition of influenza A virus infection by Galectin-9.  T. Hattori, J. Maruyama, Y. Fujioka, Y. Nakayama, Y. Ohba, T. Niki, T. Arikawa, T. Miyazaki, M. Hirashima, and H. Kida. Jpn. J. Vet. Res. 61(1&2):5-18(2013)

All members of the EPI64 subfamily of TBC/RabGAPs also have GAP activities toward Ras. H. Nagai, S. Yasuda, Y. Ohba, M. Fukuda, and T. Nakamura. J. Biochem. 153(5): 283-288 (2013)

2012年

Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1. S. Chiba, M. Baghdadi, H. Akiba, H. Yoshiyama, I. Kinoshita, H. Dosaka-Akita, Y. Fujioka, Y. Ohba, J.V. Gorman, J.D. Colgan, M. Hirashima, T. Uede, A. Takaoka, H. Yagita and M. Jinushi. Nat. Immunol. 13(9): 832–842 (2012)

Simultaneous inhibition of Src and Aurora kinases by SU6656 induces therapeutic synergy in human synovial sarcoma growth, invasion, and angiogenesis in vivo. R. Arai, M. Tsuda*, T. Watanabe, T. Ose, C. Obuse, K. Maenaka, A. Minami and Y. Ohba. Eur. J. Cancer 48(15): 2417-2430 (2012)

2011年

DJ-1 associates with synaptic membranes. Y. Usami, T. Hatano, S. Imai, SI. Kubo, S. Sato, S. Saiki, Y. Fujioka, Y. Ohba, F. Sato, M. Funayama, H. Eguchi, K. Shiba, H. Ariga, J. Shen, N. Hattori. Neurobiol. Dis. 43(3): 651-662 (2011)

RANKL expression specifically observed in vivo promotes epithelial mesenchymal transition and tumor progression. T. Yamada, M. Tsuda, T. Takahashi, Y. Totsuka, M. Shindoh and Y. Ohba*. Am. J. Pathol. 178(6): 2845-2856 (2011)

IRF3 regulates cardiac fibrosis but not hypertrophy in mice during angiotensin II-induced hypertension. K. Tsushima, T. Osawa, H. Yanai, A. Nakajima, A. Takaoka, I. Manabe, Y. Ohba, Y. Imai, T. Taniguchi and R. Nagai. FASEB J. 25(5): 1531-1543 (2011)

The Ras–PI3K Signaling Pathway Is Involved in Clathrin-Independent Endocytosis and the Internalization of Influenza Viruses. Y.Fujioka, M. Tsuda, T. Hattori, J. Sasaki, T. Sasaki, T. Miyazaki & Y. Ohba*. PLoS One 6(1): e16324 (2011)Hattori, J. Sasaki, T. Sasaki, T. Miyazaki & Y. Ohba*. PLoS One 6(1): e16324 (2011)

北大によるプレスリリース記事
Nature Asia

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species. K. Atarashi, T. Tanoue, T. Shima, A. Imaoka, T. Kuwahara, Y. Momose, G. Cheng, S. Yamasaki, T. Saito, Y. Ohba, T. Taniguchi, K. Takeda, S. Hori, I.I. Ivanov, Y. Umesaki, K. Itoh & K. Honda. Science 331(6015): 337-341 (2011) 

ZAPS is a potent stimulator of RIG-I-mediated signaling for antiviral response. S. Hayakawa, S. Shiratori, H. Yamato, T. Kameyama, C. Kitatsuji, F. Kashigi, S. Goto, S. Kameoka, D. Fujikura, T. Yamada, T. Mizutani, M. Kazumata, M. Sato, J. Tanaka, M. Imamura, M. Asaka, Y. Ohba, T. Miyazaki & A. Takaoka. Nat. Immunol. 12(1): 37-44 (2011)

cover of this issue:

2010年

Conversion of Helicobacter pylori CagA from senescence inducer to oncogenic driver through polarity-dependent regulation of p21. Y. Saito, N. Murata-Kamiya, Y. Ohba & M. Hatakeyama. J. Exp. Med. 207(10): 2157-2174 (2010)

A novel FRET-based biosensor for the measurement of BCR-ABL activity and its response to drugs in living cells. T. Mizutani, T. Kondo, S. Darmanin, M. Tsuda, S. Tanaka, M. Tobiume, M. Asaka, & Y. Ohba*. Clin. Cancer Res. 16(15): 3964-3975 (2010)

 Commentary on this paper: Clin. Cancer Res. 16(15): 3822-3824 (2010)

2009年

Increased motility and invasiveness of tumor cells that survived 10 Gy irradiation. K. Tsutsumi, M. Tsuda, N. Yazawa, H. Nakamura, S. Ishihara, H. Haga, M. Yasuda, R. Yamazaki, H. Shirato,H. Kawaguchi, T. Nishioka, Y. Ohba. Cell Struct. Funct. 34(2): 89-96 (2010)

The adaptor protein Crk induces Src-dependent activation of p38 MAPK in regulation of synovial sarcoma cell proliferation. T. Watanabe, M. Tsuda, S. Tanaka, Y. Ohba, H. Kawaguchi, T. Majima, H. Sawa, & A. Minami. Mol. Cancer Res. 7(9): 1582-1592 (2009)

Visualization of Ras-PI3K interaction in the endosome using BiFC. K. Tsutsumi, Y. Fujioka, M. Tsuda,H. Kawaguchi, Y. Ohba*. Cell Signal. 21(11): 1672-1679 (2009)

Helicobacter pylori CagA causes mitotic impairment and induces chromosomal instability. M. Umeda, N. Murata-Kamiya, Y. Saito, Y. Ohba, M. Takahashi, & M. Hatakeyama. J. Biol. Chem. 284(33): 22166-22172 (2009)

Parkin stabilizes PINK1 through direct interaction. K. Shiba, T. Arai, S. Sato, SI. Kubo, Y. Ohba, Y. Mizuno, & N. Hattori. Biochem. Biophys. Res. Commun. 583(3): 331-335 (2009)

Integral role of transcription factor 8 in the negative regulation of tumor angiogenesis. T. Inuzuka, M. Tsuda, H. Kawaguchi, Y. Higashi, & Y. Ohba*. Cancer Res. 69(4): 1678-1684 (2009)

Transcription factor 8 activates R-Ras to regulate angiogenesis. T. Inuzuka, M. Tsuda, H. Kawaguchi, & Y. Ohba* Biochem. Biophys. Res. Commun. 379(2): 510-513 (2009)

2008年

Clinicopathological significance of expression of p-c-Jun, TCF4 and beta-Catenin in colorectal tumors. K. Takeda, I. Kinoshita, Y. Shimizu, Y. Ohba, T. Itoh, Y. Matsuno, & H. Dosaka-Akita. BMC-Cancer 8: 328 (2008)

PTHrP promotes malignancy of human oral cancer cell downstream of the EGFR signaling. T. Yamada, M. Tsuda, Y. Ohba*, H. Kawaguchi, Y. Totsuka, & M. Shindoh. Biochem. Biophys. Res. Commun. 368(3): 575-581 (2008)

Homeostatic erythropoiesis by the transcription factor IRF2 through attenuation of type I interferon signaling. T. Mizutani, K. Tsuji, Y. Ebihara, S. Taki, Y. Ohba, T. Taniguchi, & K. Honda. Exp. Hematol. 36(3): 255-264 (2008)

2007年

OLIG2 inhibits the motility of a human glial tumor cell line by activating RhoA. K. Tabu, Y. Ohba, T. Suzuki, Y. Makino, T. Kimura, A. Ohnishi, M. Sakai, T. Watanabe, S. Tanaka & H. Sawa. Mol. Cancer Res. 5(10): 1099-1109 (2007)

DAI (DLM1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. A. Takaoka, Z. C. Wang, M. K. Choi, H. Yanai, H. Negishi, T. Ban, M. Miyagishi, K. Honda, Y. Ohba & T. Taniguchi. Nature 448(7152): 501-505 (2007)

Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA. K. Funami, M. Sasai, Y. Ohba, H. Oshiumi, T. Seya & M. Matsumoto. J. Immunol. 179(10): 6867-6872 (2007)

Location of possible miRNA processing site in SmD3/SmB nuclear bodies in Arabidopsis. Y. Fujioka, M. Utsumi, Y. Ohba & Y. Watanabe. Plant Cell Physiol. 48(9): 1243-1253 (2007)

Differential Ras activation between caveolae/raft and non-raft microdomains. T. Fukano, A. Sawano, Y. Ohba, M. Matsuda, & A. Miyawaki. Cell Struct. Funct. 32(1):9-15 (2007).

2006年

Differential contribution of Puma and Noxa in dual regulation of p53-mediated apoptotic pathways. T. Shibue, S. Suzuki, H. Okamoto, H. Yoshida, Y. Ohba, A. Takaoka & T. Taniguchi. EMBO J. 25(20): 4952-62 (2006)

Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program. H. Negishi, Y. Fujita, H. Yanai, S. Sakaguchi, X. Ouyang, M. Shinohara, H. Takayanagi, Y. Ohba T. Taniguchi, & K. Honda. Proc. Natl. Acad. Sci. USA 103(41): 15136-15141 (2006)

2005年以前

 東京大学(谷口研)

Negative regulation of Toll-like receptor signaling by IRF-4. H. Negishi†, Y. Ohba†, H. Yanai, A. Takaoka, K. Honma, K. Yui, T. Matsuyama, T. Taniguchi & K. Honda. Proc. Natl Acad. Sci. U.S.A. 102: 15989-15994 (2005) [†, equal contribution]

Spatiotemporal regulation of MyD88-IRF-7 signalling pathway for robust type-I interferon induction. K. Honda†, Y. Ohba†, H. Yanai†, H. Negishi, T. Mizutani, A. Takaoka, C. Taya & T. Taniguchi. Nature 434(7036): 1035-1040 (2005) [†, equal contribution]

IRF-7 is the master regulator of type-1 interferon-dependent immune responses. K. Honda, H. Yanai, H. Negishi, T. Mizutani, M. Asagiri, M. Sato, N. Shimada, Y. Ohba, A. Takaoka, N. Yoshida & T. Taniguchi. Nature 434(7034): 772-777 (2005)

Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors. A. Takaoka, H. Yanai, S. Kondo, G. Duncan, H. Negishi, T. Mizutani, S. Kano, K. Honda, Y. Ohba, T. Mak & T. Taniguchi. Nature 434(7030): 243-249 (2005)

Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling. K. Honda, H. Yanai, T. Mizutani, H. Negishi, N. Shimada, N. Suzuki, Y. Ohba, A. Takaoka, W. C. Yeh & T. Taniguchi. Proc. Natl. Acad. Sci. U.S.A.101(43): 15416-15421 (2004)

 大阪大学(松田研)

STAT3 noncell-autonomously controls planar cell polarity during zebrafish convergence and extension. C. Miyagi, S. Yamashita, Y. Ohba, H. Yoshizaki, M. Matsuda & T. Hirano. J. Cell Biol. 166(7): 975-981 (2004)

Cell Type-specific Regulation of RhoA Activity during Cytokinesis. H. Yoshizaki, Y. Ohba, M.C. Parrini, N. G. Dulyaninova, A. R. Bresnick, N. Mochizuki & M. Matsuda. J. Biol. Chem. 279(43): 44756-44762 (2004)

RalA Activation at Nascent Lamellipodia of EGF-stimulated Cos7 cells and Migrating MDCK Cells. A. Takaya, Y. Ohba, K. Kurokawa & M. Matsuda. Mol. Biol. Cell 15(6): 2549-2557 (2004)

Co-activation of Rac1 and Cdc42 at Lamellipodia and Membrane Ruffles Induced by Epidermal Growth Factor. K. Kurokawa, R. E. Itoh, H. Yoshizaki, Y. Ohba, T. Nakamura & M. Matsuda. Mol. Biol. Cell 15(3): 1003-1010 (2004)

Activity of Rho-family GTPases during cell division as visualized with FRET-based probes. H. Yoshizaki, Y. Ohba, K. Kurokawa, R. E. Itoh, T. Nakamura, N. Mochizuki, K. Nagashima & M. Matsuda. J. Cell Biol. 162(2): 223-232 (2003)

Mechanism of the spatio-temporal regulation of Ras and Rap1. Y. Ohba, K. Kurokawa & M. Matsuda. EMBO J. 22(4): 859-869 (2003)

Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway-mediated Rap1 activation. A. Sakakibara, Y. Ohba, K. Kurokawa, M. Matsuda & S. Hattori. J. Cell Sci. 115(Pt 24): 4915-4924 (2002)

Activation of rac and cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cells. R. E. Itoh, K. Kurokawa, Y. Ohba, H. Yoshizaki, N. Mochizuki & M. Matsuda. Mol. Cell. Biol. 22(18): 6582-6591 (2002)

Spatio-temporal images of growth-factor-induced activation of Ras and Rap1. N. Mochizuki, S. Yamashita, K. Kurokawa, Y. Ohba, T. Nagai, A. Miyawaki & M. Matsuda. Nature 411(6841): 1065-1068 (2001)

A pair of fluorescent resonance energy transfer-based probes for tyrosine phosphorylation of the CrkII adaptor protein in vivo. K. Kurokawa, N. Mochizuki, Y. Ohba, H. Mizuno, A. Miyawaki & M. Matsuda. J. Biol. Chem. 276(33): 31305-31310 (2001)

 国立国際医療センター(松田研)

Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis. Y. Ohba, K. Ikuta, A. Ogura, J. Matsuda, N. Mochizuki, K. Nagashima, K. Kurokawa, B. J. Mayer, K. Maki, J. Miyazaki & M. Matsuda. EMBO J. 20(13): 3333-3341 (2001)

Rap2 as a slowly responding molecular switch in the rap1 signaling cascade. Y. Ohba, N. Mochizuki, K. Matsuo, S. Yamashita, M. Nakaya, Y. Hashimoto, M. Hamaguchi, T. Kurata, K. Nagashima & M. Matsuda. Mol. Cell. Biol. 20(16): 6074-6083 (2000)

CalDAG-GEFIII Activation of Ras, R-Ras and Rap1. S. Yamashita, N. Mochizuki, Y. Ohba, M. Tobiume, Y. Okada, H. Sawa, K. Nagashima and M. Matsuda. J. Biol. Chem. 275(33): 25488-25493 (2000)

Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3. Y. Ohba, N. Mochizuki, S. Yamashita, A. M. Chan, J. W. Schrader, S. Hattori, K. Nagashima & M. Matsuda. J. Biol. Chem. 275(26): 20020-20026 (2000)

Crk Activation of JNK via C3G and R-Ras. N. Mochizuki, Y. Ohba, S. Kobayashi, N. Otsuka, A. M. Graybiel, S. Tanaka & M. Matsuda. J. Biol. Chem. 275(17): 12667-12671 (2000)

Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with Gai. N. Mochizuki, Y. Ohba, E. Kiyokawa, T. Kurata, T. Murakami, T. Ozaki, A. Kitabatake, K. Nagashima & M. Matsud.  Nature 400(6747): 891-4 (1999)

 北海道大学(長嶋研)

Eosinophilic inclusions in ependymoma represent microlumina: a light and electron microscopic study. N. Kawano, Y. Ohba & K. Nagashima. Acta Neuropathol. 99(2): 214-218 (2000)

Melanotic peritoneal sarcomatosis originating from clear cell sarcoma. Y. Ohba, H. Suzuki, H. Hiraga, T. Ito, H. Sawa, M. Nagai, S.I. Satoh, H. Iwaki & K. Nagashima. Pathol. Int. 49(7): 653-657 (1999)

英文総説

Fluorescence bioimaging of intracellular signaling and its clinical application. Y. Ohba and Y. Fujioka. J. Oral Biosci. 58(4): 113–119 (2016)

Fluorescent protein-based biosensors to visualize signal transduction beneath the plasma membrane.Y. Fujioka, A. Nanbo, S.Y. Nishide and Y. Ohba Anal. Sci. 31(4): 267-274 (2015)

和文総説等

少数の要素を計測する―ウイルス何個で“感染”するか?. 藤岡容一朗, 田端和仁, 大場雄介, 野地博行. 実験医学 35: 3197–3203 (2017)

Ras-PI3Kシグナルによるエンドサイトーシスとウイルス粒子取り込みの制御機構. 藤岡容一朗, 大場雄介. 生化学 87(1): 91-100 (2015)

[特集]細胞の少数制と多様性に挑むシングルセルアナリシス―患者血液とFRETバイオセンサーを用いた薬効効果予測. 大場雄介. 生体の科学(金原出版)65(2): 171-175 (2014)

FRETを用いた分子標的治療薬の耐性判定技術. 大場雄介, 津田真寿美. 生化学 84(5): 359-365 (2012)

実験技術:蛍光タンパク質を用いた細胞内シグナル伝達の可視化. 大場雄介, 津田真寿美. 日薬理誌 138: 271-275 (2011)

蛍光タンパク質を用いた白血病分子標的治療薬の効果判定技術. 大場雄介. バイオインダストリー 28(2): 33-39(2011)

バイオイメージングの基礎と応用. 津田真寿美, 大場雄介. 細胞 41(11): 462-463 (2009)

細胞内シグナル伝達の可視化とその創薬への応用. 大場雄介, 津田真寿. 実験医学(増刊号) 6: 2506-2513 (2008)

細胞増殖と細胞死:大場雄介, 松田道行 病理と臨床(臨時増刊号)22: 75-80 (2004)

がん遺伝子産物Rasの情報伝達とその可視化:大場雄介, 松田道行 生化学 76: 16-28 (2004)

生きた細胞を使った癌遺伝子研究―その新しい動き:大場雄介 医学のあゆみ 203: 248-250 (2002)

三量体Gタンパク質による低分子量Gタンパク質の活性化機構とMAPキナーゼの活性化:大場雄介, 望月直樹, 松田道行 実験医学 18: 1373-1378 (2000)

Ras/Rap1/Rho:大場雄介, 松田道行 Bio Science 新用語ライブラリー免疫[第2版](斉藤隆,竹森利忠編)羊土社東京: 126-127 (2000)

脊髄腫瘍 (3) 髄膜腫:大場雄介, 長嶋和郎 Clinical Neuroscience 15: 12-13 (1997)