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Research papers

English Theses

2017

47.  Improved FRET biosensor for the measurement of BCR-ABL activity in chronic myeloid leukemia cells. M. Horiguchi, M. Fujioka, T. Kondo, Y. Fujioka, X. Li, K. Horiuchi, A.O. Satoh, P. Nepal, S. Nishide, A. Nanbo, T. Teshima and Y. Ohba. Cell. Struct. Funct. 42(1): 15-26 (2017)

 

2016

46. Epstein-Barr virus exploits host endocytic machinery for cell-to-cell viral transmission rather than a virological synapse. A. Nanbo, K. Kachi, H. Yoshiyama and Y. Ohba. J. Gen. Virol. 97(11): 2989-3006 (2016)
45. Tumour endothelial cells in high metastatic tumours promote metastasis via epigenetic dysregulation of biglycan. N. Maishi, Y. Ohba, K. Akiyama, N. Ohga, J.I. Hamada, H. Nagao-Kitamoto, M. Alam, K. Yamamoto, T. Kawamoto, N. Inoue, A. Taketomi, M. Shindoh, Y. Hida and K. Hida. Sci. Rep. 6: 28039 (2016)
44.  Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia. R. Okumura, T. Kurakawa, T. Nakano, H. Kayama, M. Kinoshita, D. Motooka, K. Gotoh, T. Kimura, N. Kamiyama, T. Kusu, Y. Ueda, H. Wu, H. Iijima, S. Barman, H. Osawa, H. Matsuno, J. Nishimura, Y. Ohba, S. Nakamura, T. Iida, M. Yamamoto, E. Umemoto, K. Sano and K. Takeda. Nature 532(7597): 117-121 (2016)
43.  Receptor activator of NF-κB ligand induces cell adhesion and integrin α2 expression via NF-κB in head and neck cancers. T. Yamada, M. Tsuda, T. Wagatsuma, Y. Fujioka, M. Fujioka, A.O. Satoh, K. Horiuchi, S. Nishide, A. Nanbo, Y. Totsuka, H. Haga, S. Tanaka, M. Shindoh, and Y. Ohba. Sci. Rep. 6: 23545 (2016)
42.  Attenuation of ligand-induced activation of angiotensin II type 1 receptor signaling by the type 2 receptor via protein kinase C. T. Inuzuka, Y. Fujioka, M. Tsuda, M. Fujioka, A.O. Satoh, K. Horiuchi, S. Nishide, A. Nanbo, S. Tanaka, and Y. OhbaSci. Rep.6:21613 (2016)
41. A role of the sphingosine-1-phosphate (S1P)-S1P receptor 2 pathway in Epithelial Defense Against Cancer (EDAC). S. Yamamoto, Y. Yako, Y. Fujioka, M. Kajita, T. Kameyama, S. Kon, S. Ishikawa, Y. Ohba, Y. Ohno, A. Kihara, and Y. Fujita. Mol. Biol. Cell 27(3): 491-499 (2016)

 

2015

40. Tyr724 phosphorylation of ELMO1 by Src is involved in cell spreading and migration via Rac1 activation.Y. Makino, M. Tsuda, Y. Ohba, H. Nishihara, H. Sawa, K. Nagashima, and S. Tanaka.Cell Commun. Signal. 13: 42 (2015)
39. Molecular role of RNF43 in canonical and noncanonical Wnt signaling.T. Tsukiyama, A. Fukui, S. Terai, Y. Fujioka, K. Shinada, H. Takahashi, T.P. Yamaguchi, Y. Ohba, and S. Hatakeyama.Mol. Cell. Biol. 35(11): 2007-2023 (2015)
38.

Adaptor protein CRK induces epithelial-mesenchymal transition and metastasis of bladder cancer cells through HGF/c-Met feedback loop. R. Matsumoto, M. Tsuda, L. Wang, N. Maishi, T. Abe, T. Kimura, M. Tanino, H. Nishihara, K. Hida, Y. Ohba, N. Shinohara, K. Nonomura, and S. Tanaka.Cancer Sci.106(6): 709-17 (2015)

37.

P18/Stathmin1 is regulated by miR-31 in ovarian cancer in response to taxane.M.K. Hassan, H. Watari, T. Mitamura, Z. Mohamed, S.F. EL-khamisy, Y. Ohba, and N. Sakuragi.Oncoscience 2(3): 294-308 (2015)

36.

Inhibition of multidrug transporter in tumor endothelial cells enhances antiangiogenic effects of low dose metronomic paclitaxel.K. Akiyama, N. Ohga, Y. Hida, N. Maishi, Y. Ohba, A.M. Towfik, T. Kawamoto, H. Ohmura, K. Yamada, C. Torii, M. Shindoh, and K. Hida.Am. J. Pathol. 185(2): 572-580 (2015)

  

2014

35. Agonist-promoted ubiquitination differentially regulates receptor trafficking of endothelin type A and type B receptors. K. Terada, T. Horinouchi, Y. Fujioka, T. Higashi, P. Nepal, M. Horiguchi, S. Karki, C.Hatate, A. Hoshi, T. Harada, Y. Mai, Y. Ohba, and S. Miwa.J. Biol. Chem. 289(51): 35283-95 (2014)
34.

Sustained elevation of Snail promotes Glial-Mesenchymal Transition after irradiation in malignant glioma.R. Mahabir, M, Tanino, E. Aiman, L. Wang, T. Kimura, T. Itoh, Y. Ohba, H. Nishihara, H. Shirato, M. Tsuda, and S. Tanaka.Neuro-Oncology 6(5): 671-685 (2014)

33.

Histone Deacetylase Inhibitors Sensitize Lung Cancer Cells to Hyperthermia: Involvement of Ku70/SirT-1 in Thermo-Protection.M. K. Hassan, H. Watari, A.E. Salah-Eldin, A.S. Sultan, Z. Mohamed, Y. Fujioka, Y. Ohba, and N. Sakuragi.PLoS One 9(4): e94213 (2014)

32.

Lysosomal interaction of Akt with Phafin2: a critical step in the induction of autophagy.M. Matsuda-Lennikov, F. Suizu, N. Hirata, M. Hashimoto, K. Kimura, T. Nagamine, Y. Fujioka, Y. Ohba, T. Iwanaga, and M. Noguchi.PLoS One 9(1): e79795 (2014)

  

2013

31. A Ca2+-dependent signalling circuit regulates influenza A virus internalisation and infection.Y. Fujioka, M. Tsuda, A. Nanbo, T. Hattori, J. Sasaki, T. Sasaki, T. Miyazaki, and Y. Ohba*. Nat. Commun. 4: 2763 (2013)
30.

Beneficial innate signaling interference for anti-bacterial responses by a TLR-mediated enhancement of the MKP-IRF3 axis.H. Negishi, K. Matsuki, N. Endo, H. Sarashina, S. Miki, A. Matsuda,K.Fukazawa, N. Taguchi-Atarashi, H. Ikushima, H. Yanai, J. Nishio, K. Honda, Y. Fujioka, Y. Ohba, T.Noda,S.Taniguchi, E. Nishida, Y. Zhang, H. Chi, R. A. Flavell, and T. Taniguchi.Proc. Natl. Acad. Sci. U.S.A. 110(49): 19884-19889 (2013)

29. Inhibition of influenza A virus infection by Galectin-9.  T. Hattori, J. Maruyama, Y. Fujioka, Y. Nakayama, Y. Ohba, T. Niki, T. Arikawa, T. Miyazaki, M. Hirashima, and H. Kida. Jpn. J. Vet. Res. 61(1&2):5-18(2013)
28

All members of the EPI64 subfamily of TBC/RabGAPs also have GAP activities toward Ras. H. Nagai, S. Yasuda, Y. Ohba, M. Fukuda, and T. Nakamura. J. Biochem. 153(5): 283-288 (2013)

 

 

2012

27. Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1. S. Chiba, M. Baghdadi, H. Akiba, H. Yoshiyama, I. Kinoshita, H. Dosaka-Akita, Y. Fujioka, Y. Ohba, J.V. Gorman, J.D. Colgan, M. Hirashima, T. Uede, A. Takaoka, H. Yagita and M. Jinushi. Nat. Immunol. 13(9): 832–842 (2012)
26. Simultaneous inhibition of Src and Aurora kinases by SU6656 induces therapeutic synergy in human synovial sarcoma growth, invasion, and angiogenesis in vivo. R. Arai, M. Tsuda*, T. Watanabe, T. Ose, C. Obuse, K. Maenaka, A. Minami and Y. Ohba. Eur. J. Cancer 48(15): 2417-2430 (2012)

 

2011

25.

DJ-1 associates with synaptic membranes. Y. Usami, T. Hatano, S. Imai, SI. Kubo, S. Sato, S. Saiki, Y. Fujioka, Y. Ohba, F. Sato, M. Funayama, H. Eguchi, K. Shiba, H. Ariga, J. Shen, N. Hattori. Neurobiol. Dis. 43(3): 651-662 (2011)

24.

RANKL expression specifically observed in vivo promotes epithelial mesenchymal transition and tumor progression. T. Yamada, M. Tsuda, T. Takahashi, Y. Totsuka, M. Shindoh and Y. Ohba*. Am. J. Pathol. 178(6): 2845-2856 (2011)

23.  IRF3 regulates cardiac fibrosis but not hypertrophy in mice during angiotensin II-induced hypertension. K. Tsushima, T. Osawa, H. Yanai, A. Nakajima, A. Takaoka, I. Manabe, Y. Ohba, Y. Imai, T. Taniguchi and R. Nagai. FASEB J. 25(5): 1531-1543 (2011)
22.

The Ras–PI3K Signaling Pathway Is Involved in Clathrin-Independent Endocytosis and the Internalization of Influenza Viruses. Y.Fujioka, M. Tsuda, T. Hattori, J. Sasaki, T. Sasaki, T. Miyazaki & Y. Ohba*. PLoS One 6(1): e16324 (2011)

21.

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species. K. Atarashi, T. Tanoue, T. Shima, A. Imaoka, T. Kuwahara, Y. Momose, G. Cheng, S. Yamasaki, T. Saito, Y. Ohba, T. Taniguchi, K. Takeda, S. Hori, I.I. Ivanov, Y. Umesaki, K. Itoh & K. Honda. Science 331(6015): 337-341 (2011) 

20.

ZAPS is a potent stimulator of RIG-I-mediated signaling for antiviral response. S. Hayakawa, S. Shiratori, H. Yamato, T. Kameyama, C. Kitatsuji, F. Kashigi, S. Goto, S. Kameoka, D. Fujikura, T. Yamada, T. Mizutani, M. Kazumata, M. Sato, J. Tanaka, M. Imamura, M. Asaka, Y. Ohba, T. Miyazaki & A. Takaoka. Nat. Immunol. 12(1): 37-44 (2011)

cover of this issue:

 

2010

19.

Conversion of Helicobacter pylori CagA from senescence inducer to oncogenic driver through polarity-dependent regulation of p21. Y. Saito, N. Murata-Kamiya, Y. Ohba & M. Hatakeyama. J. Exp. Med. 207(10): 2157-2174 (2010)

18.

A novel FRET-based biosensor for the measurement of BCR-ABL activity and its response to drugs in living cells. T. Mizutani, T. Kondo, S. Darmanin, M. Tsuda, S. Tanaka, M. Tobiume, M. Asaka, & Y. Ohba*. Clin. Cancer Res. 16(15): 3964-3975 (2010)

 Commentary on this paper: Clin. Cancer Res. 16(15): 3822-3824 (2010)

 

2009

17. 

Increased motility and invasiveness of tumor cells that survived 10 Gy irradiation. K. Tsutsumi, M. Tsuda, N. Yazawa, H. Nakamura, S. Ishihara, H. Haga, M. Yasuda, R. Yamazaki, H. Shirato,H. Kawaguchi, T. Nishioka, Y. Ohba. Cell Struct. Funct. 34(2): 89-96 (2010)

16.

The adaptor protein Crk induces Src-dependent activation of p38 MAPK in regulation of synovial sarcoma cell proliferation. T. Watanabe, M. Tsuda, S. Tanaka, Y. Ohba, H. Kawaguchi, T. Majima, H. Sawa, & A. Minami. Mol. Cancer Res. 7(9): 1582-1592 (2009)

15.

Visualization of Ras-PI3K interaction in the endosome using BiFC. K. Tsutsumi, Y. Fujioka, M. Tsuda,H. Kawaguchi, Y. Ohba*. Cell Signal. 21(11): 1672-1679 (2009)

14. Helicobacter pylori CagA causes mitotic impairment and induces chromosomal instability. M. Umeda, N. Murata-Kamiya, Y. Saito, Y. Ohba, M. Takahashi, & M. Hatakeyama. J. Biol. Chem. 284(33): 22166-22172 (2009)  
13. Parkin stabilizes PINK1 through direct interaction. K. Shiba, T. Arai, S. Sato, SI. Kubo, Y. Ohba, Y. Mizuno, & N. Hattori. Biochem. Biophys. Res. Commun. 583(3): 331-335 (2009)  
12.

Integral role of transcription factor 8 in the negative regulation of tumor angiogenesis. T. Inuzuka, M. Tsuda, H. Kawaguchi, Y. Higashi, & Y. Ohba*. Cancer Res. 69(4): 1678-1684 (2009)

 
11.

Transcription factor 8 activates R-Ras to regulate angiogenesis.

T. Inuzuka, M. Tsuda, H. Kawaguchi, & Y. Ohba*

Biochem. Biophys. Res. Commun. 379(2): 510-513 (2009)

 

2008

10.

Clinicopathological significance of expression of p-c-Jun, TCF4 and beta-Catenin in colorectal tumors. K. Takeda, I. Kinoshita, Y. Shimizu, Y. Ohba, T. Itoh, Y. Matsuno, & H. Dosaka-Akita. BMC-Cancer 8: 328 (2008)

9.

PTHrP promotes malignancy of human oral cancer cell downstream of the EGFR signaling. T. Yamada, M. Tsuda, Y. Ohba*, H. Kawaguchi, Y. Totsuka, & M. Shindoh. Biochem. Biophys. Res. Commun. 368(3): 575-581 (2008)

8.

Homeostatic erythropoiesis by the transcription factor IRF2 through attenuation of type I interferon signaling. T. Mizutani, K. Tsuji, Y. Ebihara, S. Taki, Y. Ohba, T. Taniguchi, & K. Honda. Exp. Hematol. 36(3): 255-264 (2008)

 

2007

7.

OLIG2 inhibits the motility of a human glial tumor cell line by activating RhoA. K. Tabu, Y. Ohba, T. Suzuki, Y. Makino, T. Kimura, A. Ohnishi, M. Sakai, T. Watanabe, S. Tanaka & H. Sawa. Mol. Cancer Res. 5(10): 1099-1109 (2007)

6.

DAI (DLM1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. A. Takaoka, Z. C. Wang, M. K. Choi, H. Yanai, H. Negishi, T. Ban, M. Miyagishi, K. Honda, Y. Ohba & T. Taniguchi. Nature 448(7152): 501-505 (2007)

5.

Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA. K. Funami, M. Sasai, Y. Ohba, H. Oshiumi, T. Seya & M. Matsumoto. J. Immunol. 179(10): 6867-6872 (2007)

4.

Location of possible miRNA processing site in SmD3/SmB nuclear bodies in Arabidopsis. Y. Fujioka, M. Utsumi, Y. Ohba & Y. Watanabe. Plant Cell Physiol. 48(9): 1243-1253 (2007)

3.

Differential Ras activation between caveolae/raft and non-raft microdomains. T. Fukano, A. Sawano, Y. Ohba, M. Matsuda, & A. Miyawaki. Cell Struct. Funct. 32(1):9-15 (2007).

 

2006

2.

Differential contribution of Puma and Noxa in dual regulation of p53-mediated apoptotic pathways. T. Shibue, S. Suzuki, H. Okamoto, H. Yoshida, Y. Ohba, A. Takaoka & T. Taniguchi. EMBO J. 25(20): 4952-62 (2006)

1.

Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program. H. Negishi, Y. Fujita, H. Yanai, S. Sakaguchi, X. Ouyang, M. Shinohara, H. Takayanagi, Y. Ohba T. Taniguchi, & K. Honda. Proc. Natl. Acad. Sci. USA 103(41): 15136-15141 (2006)

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