Promotion of cell physiology research to see, think and understand
—with “Seeing is believing” as a lab mantra—
Human cells, which number in 60 trillions, do not always remain a static state, but rather respond to environmental changes (external disturbances). Physiological functions evoked by the orchestration of such responses bring homeostasis to living organisms. Intracellular signaling dictates the maintenance of homeostasis, and is dynamically controlled by the cooperation of a series of molecular reactions. Precise regulation of intracellular signaling is what is the keystone for cells to exert accurate physiological functions. We engage in research with a goal of a comprehensive understanding of the biological phenomena through visualization of intracellular signaling and its regulation that form the core elements of the mechanism of life by using bioimaging techniques. “Seeing is believing” is the mantra of our lab.
Visualization of cell physiology
Visualization of cellular behavior
in response to environmental cues
|In response to extracellular environmental changes, cells will show a variety of behaviors. We aim to simultaneously visualize the process of signal transduction and the expression and such behaviors (cell functions), through which we would like to understand phenomena arising dynamically in living cells. In other words, our goal is to understand macroscopic events (cell behaviors and in situ or in vivo functions) by disclosing each signal transduction pathway from the microscopic view.|
|We mainly engage in studies of visualization of signal transduction pathways and the regulation of endocytosis or membrane dynamics, with the best use of live cell imaging techniques, including green fluorescent protein (GFP) and Förster/fluorescence resonance energy transfer (FRET). In the future, we would like to extend our research interests into homeostasis of biological membranes, intra- or extracellular in cell societies, by incorporating higher dimensional fluorescence imaging and operation of cell function by optogenetics.|
Field of human resource development and knowledge-building
Provision of circumstances for intellectual creation
and human resource development
for the next generation
It would be more than happy if we can launch outcomes to modify a piece of textbooks from our laboratory. It is also true that what we can do by ourselves is not so many, however. Therefore, It is, we believe, our important task to nurture bearers of the next generation. I would also like to create placemaking for all lab members to feel their growth and make their dreams come true through research activities. In particular, we would like to contribute to the development of professional researcher at the global level, not only in their current career but also in future ones.
We ask lab members (and member-to-be) to look for both of “what you want to learn or desire” and “what you can contribute to the lab.” Of course, participation in the lab is of no value to you if there is nothing to be gained from us. At the same time, little progress and achievement as a researcher (as well as in other jobs than research) would be expected when you take an only passive role in an enrolled research project, based on an inappropriate dogma that university is the place to donate education. I am confident that an individual who finds and masters full of them will do great works, develop significantly and realize his/her own development. I would like to spare no effort to provide such a vibrant milieu as to.